9-Acridinylpeptides and 9-acridinyl-4-nitrophenylsulfonylpeptides. Synthesis, binding to DNA, and photoinduced DNA cleavage.
作者信息
Karup G, Meldal M, Nielsen P E, Buchardt O
机构信息
Bioorganic Group, H.C. Orsted Institute, Copenhagen, Denmark.
出版信息
Int J Pept Protein Res. 1988 Nov;32(5):331-43.
PMID:3209353
Abstract
The preparation of 6-(9-acridinylamino)hexanoic acid DHBT ester and N alpha-Fmoc-N epsilon-(4-nitrophenylsulfonyl)-L-lysine DHBT ester and their application in solid phase peptide synthesis are described. The 9-acridinylamino ligand was shown to confer high DNA affinity, probably by intercalation, to the resulting peptides. The 4-nitrophenylsulfamido ligand furthermore resulted in "photonuclease" activity of some of the modified peptides.
摘要
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