N(α)-叔丁氧羰基-N(ε)-四苄基-DTPA-L-赖氨酸和N(α)-芴甲氧羰基-N(ε)-四叔丁基-DTPA-L-赖氨酸的合成，用于含DTPA肽固相合成的构建模块。
Synthesis of N(alpha)-Boc-N(epsilon)-tetrabenzyl-DTPA-L-lysine and N(alpha)-Fmoc-N(epsilon)-tetra-t-butyl-DTPA-L-lysine, building blocks for solid phase synthesis of DTPA-containing peptides.
作者信息
Davies John S, Al-Jamri Loai
机构信息
Department of Chemistry, University of Wales Swansea, Singleton Park, Swansea SA2 8PP, UK.
出版信息
J Pept Sci. 2002 Dec;8(12):663-70. doi: 10.1002/psc.427.
DOI:10.1002/psc.427
PMID:12523643
Abstract
Two building blocks, Boc-Lys(Bn4-DTPA)-OH and Fmoc-Lys(Bu4(t)-DTPA)-OH have been synthesized via the acylation of the epsilon-amino group of N(alpha)-protected lysine, using suitably protected tetra-esters of diethylene triamine pentaacetic acid (DTPA), a ligand with wide application as a chelating agent for complexing metal tons to peptides.
摘要
通过使用二乙烯三胺五乙酸（DTPA）的适当保护的四酯对N（α）-保护的赖氨酸的ε-氨基进行酰化反应，合成了两种结构单元，即Boc-Lys（Bn4-DTPA）-OH和Fmoc-Lys（Bu4（t）-DTPA）-OH。DTPA是一种广泛用作螯合剂以使金属离子与肽络合的配体。
Zotero 插件