Telethon Kids Institute, and
Office of the Chief Psychiatrist, Department of Health, Government of Western Australia, Perth, Australia.
Pediatrics. 2020 Mar;145(3). doi: 10.1542/peds.2019-1574. Epub 2020 Feb 24.
Investigate the relationship between maternal alcohol-use disorder and multiple biological and social child outcomes, including birth outcomes, child protection, justice contact, and academic outcomes for both Indigenous and non-Indigenous children.
Women with a birth recorded on the Western Australian Midwives Notification System (1983-2007) and their offspring were in scope. The exposed cohort were mothers with an alcohol-related diagnosis ( and ) recorded in an administrative data set and their offspring (non-Indigenous: = 13 969; Indigenous: = 9635). The exposed cohort was frequency matched with mothers with no record of an alcohol-related diagnosis and their offspring (comparison cohort; non-Indigenous: = 40 302; Indigenous: = 20 533).
Over half of exposed non-Indigenous children (55%) and 84% of exposed Indigenous children experienced ≥1 negative outcome. The likelihood of any negative outcome was significantly higher for the exposed than the comparison cohort (non-Indigenous: odds ratio [OR] = 2.67 [95% confidence interval (CI) = 2.56-2.78]; Indigenous: OR = 2.67 [95% CI = 2.50-2.85]). The odds were greatest for children whose mothers received a diagnosis during pregnancy (non-Indigenous: OR = 4.65 [95% CI = 3.87-5.59]; Indigenous: OR = 5.18 [95% CI = 4.10-6.55]); however, numbers were small.
The effects of maternal alcohol-use disorder are experienced by the majority of exposed children rather than a vulnerable subgroup of this population. These findings highlight the need for universal prevention strategies to reduce harmful alcohol use and targeted interventions to support at-risk women and children.
调查母亲酒精使用障碍与多种生物和社会儿童结局之间的关系,包括出生结局、儿童保护、司法接触以及土著和非土著儿童的学业成绩。
研究对象为在西澳大利亚助产士通知系统(1983-2007 年)中有分娩记录的妇女及其后代。暴露队列为在行政数据集记录中存在与酒精相关诊断(和)的母亲及其后代(非土著:=13969;土著:=9635)。暴露队列按频率与没有酒精相关诊断记录的母亲及其后代相匹配(对照组;非土著:=40302;土著:=20533)。
超过一半的暴露于非土著儿童(55%)和 84%的暴露于土著儿童经历了≥1种不良结局。暴露组发生任何不良结局的可能性显著高于对照组(非土著:比值比[OR] =2.67[95%置信区间(CI)=2.56-2.78];土著:OR =2.67[95% CI=2.50-2.85])。母亲在怀孕期间被诊断出患有该病的儿童的可能性最大(非土著:OR=4.65[95% CI=3.87-5.59];土著:OR=5.18[95% CI=4.10-6.55]),但数量较少。
大多数暴露于酒精的儿童会经历母亲酒精使用障碍的影响,而不是这一人群中的一个脆弱亚组。这些发现强调了需要采取普遍的预防策略来减少有害的酒精使用,并采取有针对性的干预措施来支持高危妇女和儿童。