己酮可可碱对正常血压和自发性高血压大鼠耳蜗血流的影响。

The effects of pentoxifylline on cochlear blood flow in normotensive and spontaneously hypertensive rats.

作者信息

Quirk W S, Dengerink H A, Bademian M J, Hall K W, Wright J W

机构信息

Department of Psychology, Washington State University, Pullman 99164.

出版信息

Hear Res. 1988 Nov;36(2-3):175-80. doi: 10.1016/0378-5955(88)90059-7.

DOI:10.1016/0378-5955(88)90059-7

PMID:3209490

Abstract

Normotensive and spontaneously hypertensive rats (SHRs) were given arterial infusions of saline and pentoxifylline in doses of 1.5, 2.0, and 3.0 mg/kg/min. Blood pressure decreased in a dose related fashion with increasing doses of pentoxifylline. Cochlear blood flow, measured via laser Doppler flowmeter, increased with infusion of pentoxifylline in members of both rat strains, but to a greater extent in SHRs than in normotensive animals. The mechanism of action appears to be decreased red blood cell rigidity which allows increased penetration of red blood cells into microvessels of the cochlea.

摘要

给正常血压大鼠和自发性高血压大鼠（SHRs）动脉输注生理盐水和剂量为1.5、2.0和3.0毫克/千克/分钟的己酮可可碱。随着己酮可可碱剂量的增加，血压呈剂量相关方式下降。通过激光多普勒血流仪测量的耳蜗血流量，在两种大鼠品系中，随着己酮可可碱的输注均增加，但在SHRs中增加的程度比正常血压动物更大。其作用机制似乎是红细胞刚性降低，这使得红细胞能够更多地渗透到耳蜗微血管中。