Maass B, Ludwig D
Curr Med Res Opin. 1984;9(1):52-5. doi: 10.1185/03007998409109559.
A comparative experimental study was carried out in guinea-pigs to assess the effect of pentoxifylline on inner ear perfusion. Five animals were given a single dose of 30 mg pentoxifylline per 10-minute intravenous infusion and the cochlear blood flow measured by means of the hydrogen-clearance technique before and after administration of the drug. A control group of 11 animals received the solvent only. Compared to controls, a significant increase in inner ear blood flow was observed in the pentoxifylline-treated animals. These data may explain positive clinical findings with pentoxifylline in otological disorders associated with impaired cochlear perfusion.
在豚鼠身上进行了一项对比实验研究，以评估己酮可可碱对内耳灌注的影响。给5只动物每10分钟静脉输注一次30毫克己酮可可碱的单剂量，并在给药前后通过氢清除技术测量耳蜗血流量。11只动物的对照组仅接受溶剂。与对照组相比，己酮可可碱治疗的动物内耳血流量显著增加。这些数据可能解释了己酮可可碱在与耳蜗灌注受损相关的耳科疾病中的阳性临床发现。
