Hillerdal M, Borg E, Engström B, Hultcrantz E
Department of Oto-Rhino-Laryngology, University Hospital, Uppsala, Sweden.
Acta Otolaryngol. 1987 Sep-Oct;104(3-4):243-50. doi: 10.3109/00016488709107324.
Cochlear blood flow was studied with the microsphere method in young and old normotensive and spontaneously hypertensive rats. The young animals were 3-6 months old and the old ones 18-24 months. The cochlear blood flow in young rats was 1.64 microliter/min/cochlea for the normotensive and 1.51 for the spontaneously hypertensive rats. In the old rats, the cochlear blood flow rates were 1.40 and 1.29 microliter/min/cochlea, respectively. The differences were not significant between the age groups, nor between the normotensive and spontaneously hypertensive rats. However, there was a tendency towards lower cochlear blood flow with increasing age, especially among the spontaneously hypertensive rats. The difference between young normotensive and old spontaneously hypertensive rats was significant (p less than 0.05). The group of old hypertensive rats was also the only one with evident morphological changes in the organ of Corti.
采用微球法对年轻和老年正常血压及自发性高血压大鼠的耳蜗血流进行了研究。年轻动物为3至6个月大，老年动物为18至24个月大。正常血压年轻大鼠的耳蜗血流为1.64微升/分钟/耳蜗，自发性高血压年轻大鼠为1.51微升/分钟/耳蜗。老年大鼠的耳蜗血流速率分别为1.40和1.29微升/分钟/耳蜗。年龄组之间以及正常血压和自发性高血压大鼠之间的差异均不显著。然而，随着年龄的增长，耳蜗血流有降低的趋势，尤其是在自发性高血压大鼠中。年轻正常血压大鼠和老年自发性高血压大鼠之间的差异具有显著性（p小于0.05）。老年高血压大鼠组也是唯一在柯蒂氏器有明显形态学变化的组。
