Collins P W
Department of Audiology, Institute of Laryngology and Otology, London, U.K.
Hear Res. 1988 Nov;36(2-3):249-59. doi: 10.1016/0378-5955(88)90066-4.
The effects of single and repeated combinations of gentamicin and sound on Preyer reflex and cochlear hair cells in pigmented guinea pigs have been examined. Gentamicin at 50 mg/kg for 10 days and an 8 kHz pure tone (116 dB for 60 min) cause little or no hair cell loss when given alone. In combination, hair cell loss occurs with the gentamicin and sound acting synergistically. If the pure tone is given on the first of a 10-day gentamicin course there is considerable loss of hair cells in the basal coil; if given on the 10th day the loss is several times less. Repeating the treatments after 3 weeks increases the hair cell loss and the synergistic effect. A possible explanation for the differential synergistic effect is discussed.
已研究了庆大霉素与声音单次及重复联合作用对有色豚鼠普赖尔反射及耳蜗毛细胞的影响。单独给予50mg/kg的庆大霉素10天以及8kHz纯音（116dB，持续60分钟）时，几乎不会或不会导致毛细胞损失。联合使用时，庆大霉素与声音协同作用导致毛细胞损失。如果在10天庆大霉素疗程的第一天给予纯音，基底螺旋会有相当数量的毛细胞损失；如果在第10天给予，则损失会减少几倍。3周后重复治疗会增加毛细胞损失及协同效应。文中讨论了这种差异协同效应的一种可能解释。
