Lesus J, Arias K, Kulaga J, Sobkiv S, Patel A, Babu V, Kambalyal A, Patel M, Padron F, Mozaffari P, Jayakumar A, Ghatalah L, Laban N, Bahari R, Perkins G, Lysakowski A
Dept. of Anatomy and Cell Biology, University of Illinois at Chicago, 808 S. Wood St., M/C 512, 60612, Chicago, IL, USA.
Dept. of Biological Sciences, University of Illinois at Chicago, Chicago, IL, USA.
HNO. 2019 Jun;67(6):429-433. doi: 10.1007/s00106-019-0662-2.
In several systems of the body (muscle, liver, nerves), new studies have examined the internal structure of mitochondria and brought to light striking new findings about how mitochondria are constructed and how their structure affects cell function. In the inner ear field, however, we have little structural knowledge about hair cell and supporting cell mitochondria, and virtually none about mitochondrial subtypes or how they function in health and disease. The need for such knowledge is discussed in this short review.
在人体的多个系统(肌肉、肝脏、神经)中,新的研究已经对线粒体的内部结构进行了检查,并揭示了有关线粒体如何构建以及其结构如何影响细胞功能的惊人新发现。然而,在内耳领域,我们对毛细胞和支持细胞线粒体的结构了解甚少,对于线粒体亚型或它们在健康和疾病中的功能几乎一无所知。本简短综述讨论了对这类知识的需求。