Suppr超能文献

为什么要研究内耳毛细胞线粒体?

Why study inner ear hair cell mitochondria?

作者信息

Lesus J, Arias K, Kulaga J, Sobkiv S, Patel A, Babu V, Kambalyal A, Patel M, Padron F, Mozaffari P, Jayakumar A, Ghatalah L, Laban N, Bahari R, Perkins G, Lysakowski A

机构信息

Dept. of Anatomy and Cell Biology, University of Illinois at Chicago, 808 S. Wood St., M/C 512, 60612, Chicago, IL, USA.

Dept. of Biological Sciences, University of Illinois at Chicago, Chicago, IL, USA.

出版信息

HNO. 2019 Jun;67(6):429-433. doi: 10.1007/s00106-019-0662-2.

Abstract

In several systems of the body (muscle, liver, nerves), new studies have examined the internal structure of mitochondria and brought to light striking new findings about how mitochondria are constructed and how their structure affects cell function. In the inner ear field, however, we have little structural knowledge about hair cell and supporting cell mitochondria, and virtually none about mitochondrial subtypes or how they function in health and disease. The need for such knowledge is discussed in this short review.

摘要

在人体的多个系统(肌肉、肝脏、神经)中,新的研究已经对线粒体的内部结构进行了检查,并揭示了有关线粒体如何构建以及其结构如何影响细胞功能的惊人新发现。然而,在内耳领域,我们对毛细胞和支持细胞线粒体的结构了解甚少,对于线粒体亚型或它们在健康和疾病中的功能几乎一无所知。本简短综述讨论了对这类知识的需求。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a05/8520470/6a5d26e0c17b/nihms-1526752-f0001.jpg

相似文献

1
Why study inner ear hair cell mitochondria?为什么要研究内耳毛细胞线粒体?
HNO. 2019 Jun;67(6):429-433. doi: 10.1007/s00106-019-0662-2.
2
[Regeneration of ciliated cells in the internal ear].[内耳纤毛细胞的再生]
Bull Mem Acad R Med Belg. 2002;157(5-6):251-8; discussion 258-60.
5
Changes in the inner ear structures in cystic fibrosis patients.囊性纤维化患者内耳结构的变化。
Int J Pediatr Otorhinolaryngol. 2017 Jan;92:108-114. doi: 10.1016/j.ijporl.2016.11.013. Epub 2016 Nov 16.
8
SoxC transcription factors are essential for the development of the inner ear.SoxC转录因子对于内耳的发育至关重要。
Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):14066-71. doi: 10.1073/pnas.1517371112. Epub 2015 Oct 26.
10
Regeneration and replacement in the vertebrate inner ear.脊椎动物内耳的再生与替换
Drug Discov Today. 2005 Oct 1;10(19):1307-12. doi: 10.1016/S1359-6446(05)03577-4.

引用本文的文献

4
Mitochondrial form and function in hair cells.线粒体的形态和功能在毛细胞中。
Hear Res. 2023 Feb;428:108660. doi: 10.1016/j.heares.2022.108660. Epub 2022 Nov 25.

本文引用的文献

1
Integrative functions of the mitochondrial contact site and cristae organizing system.线粒体接触点和嵴形成系统的整合功能。
Semin Cell Dev Biol. 2018 Apr;76:191-200. doi: 10.1016/j.semcdb.2017.09.021. Epub 2017 Sep 29.
4
Reconstitutions of mitochondrial inner membrane remodeling.线粒体内膜重塑的重构
J Struct Biol. 2016 Oct;196(1):20-28. doi: 10.1016/j.jsb.2016.07.014. Epub 2016 Jul 25.
6
Role of MINOS in mitochondrial membrane architecture and biogenesis.MINOS 在线粒体膜结构和生物发生中的作用。
Trends Cell Biol. 2012 Apr;22(4):185-92. doi: 10.1016/j.tcb.2012.01.004. Epub 2012 Mar 2.
9
Cisplatin ototoxicity in rat cochlear organotypic cultures.顺铂耳毒性在大鼠耳蜗器官型培养中的作用。
Hear Res. 2011 Dec;282(1-2):196-203. doi: 10.1016/j.heares.2011.08.002. Epub 2011 Aug 12.

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验