Yaghoobi Gholamhosein, Shokoohi-Rad Saeed, Jafarzadeh Hamid, Abdollahi Elham
Ophthalmology Department, Birjand University of Medical Sciences, Valiasr Hospital, Birjand, Iran.
Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
J Ophthalmic Vis Res. 2020 Feb 2;15(1):38-44. doi: 10.18502/jovr.v15i1.5940. eCollection 2020 Jan-Mar.
Pterygium is a common fibro-vascular-related eye disease. The fibroblast growth factor 21 (FGF21) helps reduce neovascularization. Previous studies have shown that the serum level of FGF21 correlates with vascular eye diseases such as diabetic retinopathy and retinopathy of prematurity. In this study, the serum FGF21 is compared in patients with and without pterygium.
This descriptive-analytical cross-sectional study examines individuals with pterygium who visited the Ophthalmology Clinic of Khatam-al-Anbia Hospital in Mashhad, Iran, during 2017-2018. Control subjects were selected from healthy people without pterygium disease. Patients with a history of acute illness, chronic liver and kidney disease, diabetes, cancer, malnutrition and drug use, women who were pregnant or breastfeeding, and subjects who were taking anticonvulsants or glucocorticoids were excluded as these may affect insulin and glycosuria levels. Sixty people (30 in each group) were chosen using the convenient sampling method. Intravenous blood samples were taken from all patients. After preparing the patients, the freeze was checked using the enzyme-linked immunosorbent assay (ELISA) method after samples had been taken. Data were analyzed by SPSS using an independent -test, Mann-Whitney, Chi-square, Kruskal-Wallis, and Kolmogorov-Smirnov tests ( = 0.05).
The serum FGF21 levels were 319.09 246.93 pg/ml and 608.88 449.81 pg/ml ( = 0.005) in the pterygium group and control subjects, respectively. The average serum FGF21 was 281.55 40.74 pg/ml in males and 361.375 10.298 pg/ml in females in the pterygium group. The difference was not statistically significant ( = 0.19).
Our study showed that FGF21 levels were lower in patients with pterygium than the control subjects to a statistically significant level.
翼状胬肉是一种常见的与纤维血管相关的眼部疾病。成纤维细胞生长因子21（FGF21）有助于减少新生血管形成。先前的研究表明，FGF21的血清水平与糖尿病视网膜病变和早产儿视网膜病变等眼部血管疾病相关。在本研究中，对有翼状胬肉和无翼状胬肉的患者的血清FGF21进行了比较。
本描述性分析横断面研究对2017年至2018年期间前往伊朗马什哈德哈塔姆-安比亚医院眼科门诊的翼状胬肉患者进行了检查。对照组从无翼状胬肉疾病的健康人群中选取。排除有急性疾病史、慢性肝肾疾病、糖尿病、癌症、营养不良和药物使用史的患者，怀孕或哺乳期妇女，以及正在服用抗惊厥药或糖皮质激素的受试者，因为这些可能会影响胰岛素和糖尿水平。采用方便抽样法选取60人（每组30人）。采集所有患者的静脉血样。在准备好患者后，采集样本后使用酶联免疫吸附测定（ELISA）方法检测血清。数据通过SPSS使用独立样本t检验、曼-惠特尼检验、卡方检验、克鲁斯卡尔-沃利斯检验和柯尔莫哥洛夫-斯米尔诺夫检验进行分析（α = 0.05）。
翼状胬肉组和对照组的血清FGF21水平分别为319.09±246.93 pg/ml和608.88±449.81 pg/ml（P = 0.005）。翼状胬肉组男性的平均血清FGF21为281.55±40.74 pg/ml，女性为361.375±10.298 pg/ml。差异无统计学意义（P = 0.19）。
我们的研究表明，翼状胬肉患者的FGF21水平低于对照组，且具有统计学意义。
