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脑室内给药。

Intracerebroventricular drug administration.

作者信息

Atkinson Arthur J

机构信息

Department of Pharmacology, Feinberg School of Medicine, Northwestern University Chicago, Illinois, USA.

出版信息

Transl Clin Pharmacol. 2017 Sep;25(3):117-124. doi: 10.12793/tcp.2017.25.3.117. Epub 2017 Sep 15.

DOI:10.12793/tcp.2017.25.3.117
PMID:32095461
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7033376/
Abstract

Among the various routes of drug administration, perhaps the least studied is intracerebroventricular (ICV) administration. This route has been shown to be particularly useful in administering to the central nervous system (CNS) drugs that do not cross the blood-brain barrier readily. As such, the ICV route is a valuable option for providing therapeutic CNS drug concentrations to treat patients with CNS infectious and neoplastic diseases. This route of drug administration also has the advantage of minimizing systemic toxicity.

摘要

在各种给药途径中，研究最少的可能是脑室内（ICV）给药。已证明这种给药途径在向中枢神经系统（CNS）给药不易穿过血脑屏障的药物时特别有用。因此，脑室内给药途径是提供治疗性中枢神经系统药物浓度以治疗中枢神经系统感染性和肿瘤性疾病患者的宝贵选择。这种给药途径还具有将全身毒性降至最低的优点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d2/7033376/7d6e13e31985/tcp-25-117-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d2/7033376/7d6e13e31985/tcp-25-117-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d2/7033376/7d6e13e31985/tcp-25-117-g001.jpg

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