环曲病毒动态变化与肺移植中的原发性移植物功能障碍相关。
Anellovirus Dynamics Are Associated With Primary Graft Dysfunction in Lung Transplantation.
作者信息
Blatter Joshua A, Takahashi Tsuyoshi, Mittler Brigitte, Nava Ruben G, Puri Varun, Kreisel Daniel, Wang David
机构信息
Department of Pediatrics, Washington University School of Medicine, St. Louis, MO.
Department of Surgery, Washington University School of Medicine, St. Louis, MO.
出版信息
Transplant Direct. 2020 Jan 13;6(2):e521. doi: 10.1097/TXD.0000000000000969. eCollection 2020 Feb.
UNLABELLED
Primary graft dysfunction (PGD) is the leading cause of early death in lung transplant. Anelloviruses are small circular DNA viruses that have been noted to be present at elevated levels in immunosuppressed patients. They have been associated with both short- and long-term outcomes in lung transplant, and we hypothesized that anellovirus dynamics might be associated with the development of PGD.
METHODS
We analyzed alphatorquevirus (ie, an anellovirus genus) levels in whole blood samples from 64 adult lung transplant recipients.
RESULTS
Patients with a relatively rapid rise in alphatorquevirus levels in the week following transplant were less likely to develop higher-grade PGD over the first 3 days following transplant ( = 0.031).
CONCLUSIONS
This study is the first to establish an association between the development of PGD and a component of the blood virome. While it is not known whether anelloviruses directly affect outcomes in lung transplant, they may serve as a biomarker of immune status in lung transplant recipients.
未标注
原发性移植肺功能障碍（PGD）是肺移植早期死亡的主要原因。微小病毒是一种小型环状DNA病毒，在免疫抑制患者中其水平会升高。它们与肺移植的短期和长期结果均有关联，我们推测微小病毒动态变化可能与PGD的发生有关。
方法
我们分析了64名成年肺移植受者全血样本中的α-环曲病毒（即微小病毒属）水平。
结果
移植后一周内α-环曲病毒水平相对快速上升的患者，在移植后的前3天内发生更高级别PGD的可能性较小（P = 0.031）。
结论
本研究首次证实PGD的发生与血液病毒组的一个组成部分之间存在关联。虽然尚不清楚微小病毒是否直接影响肺移植的结果，但它们可能作为肺移植受者免疫状态的生物标志物。
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