Lu Liping, Chen Cheng, Yang Kefeng, Zhu Jie, Xun Pengcheng, Shikany James M, He Ka
Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, USA.
Department of Epidemiology, Columbia University Mailman School of Public Health, New York, USA.
Eur J Nutr. 2020 Dec;59(8):3745-3753. doi: 10.1007/s00394-020-02206-3. Epub 2020 Feb 24.
Although laboratory studies suggest a potential role of magnesium (Mg) in weight regulation, human studies relating Mg intake to body weight are limited. This study sought to prospectively examine the association between Mg intake and incidence of obesity and related anthropometric and biochemical indicators.
The Coronary Artery Risk Development in Young Adults (CARDIA) study recruited 5115 American young adults, aged 18-30 years, at baseline in 1985-6, and re-examined them in eight follow-ups. Incident obesity was defined as body mass index (BMI) ≥ 30 kg/m. Dietary Mg intake was collected using the CARDIA Diet History at baseline and exam years 7 and 20.
During the 30-year follow-up, 1675 incident cases of obesity were identified. After adjustment for potential confounders, Mg intake was inversely associated with incidence of obesity. The multivariable-adjusted hazard ratios (95% confidence interval) from quintile 1 (Q1) (lowest intake group) to quintile 5 (Q5) (highest intake group) were 1 (referent), 0.86 (0.74, 1.00), 0.83 (0.71, 0.97), 0.55 (0.46, 0.66), and 0.49 (0.40, 0.60); P for trend < 0.01. Consistently, Mg intake was inversely associated with the levels of BMI, triceps skinfold, suprailiac skinfold, subscapular skinfold, fasting insulin, and C-reactive protein. The observed associations were not materially modified by age, sex, race, or BMI at baseline. In addition, the intakes of foods rich in Mg, including whole grains, nuts and seeds, legumes, and dark-green vegetables, were associated with lower incidence of obesity.
This longitudinal study suggests that Mg intake is inversely associated with incidence of obesity.
尽管实验室研究表明镁（Mg）在体重调节中可能发挥作用，但关于镁摄入量与体重关系的人体研究有限。本研究旨在前瞻性地探讨镁摄入量与肥胖发生率以及相关人体测量和生化指标之间的关联。
青年成人冠状动脉风险发展（CARDIA）研究在1985 - 1986年基线时招募了5115名18 - 30岁的美国青年成人，并在八次随访中对他们进行重新检查。新发肥胖定义为体重指数（BMI）≥30 kg/m²。在基线以及第7年和第20年检查时，使用CARDIA饮食史收集饮食镁摄入量。
在30年的随访期间，共确定了1675例新发肥胖病例。在对潜在混杂因素进行调整后，镁摄入量与肥胖发生率呈负相关。从第1五分位数（Q1）（最低摄入量组）到第5五分位数（Q5）（最高摄入量组）的多变量调整风险比（95%置信区间）分别为1（参照）、0.86（0.74，1.00）、0.83（0.71，0.97）、0.55（0.46，0.66）和0.49（0.40，0.60）；趋势P值<0.01。一致地，镁摄入量与BMI、肱三头肌皮褶厚度、髂上皮肤褶厚度、肩胛下皮肤褶厚度、空腹胰岛素和C反应蛋白水平呈负相关。观察到的关联在基线时不受年龄、性别、种族或BMI的实质性影响。此外，富含镁的食物摄入量，包括全谷物、坚果和种子、豆类以及深绿色蔬菜，与较低的肥胖发生率相关。
这项纵向研究表明，镁摄入量与肥胖发生率呈负相关。
