Vuksan V, Jenkins A L, Brissette C, Choleva L, Jovanovski E, Gibbs A L, Bazinet R P, Au-Yeung F, Zurbau A, Ho H V T, Duvnjak L, Sievenpiper J L, Josse R G, Hanna A
Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Division of Endocrinology & Metabolism, St. Michael's Hospital, Toronto, ON, Canada.
Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON, Canada.
Nutr Metab Cardiovasc Dis. 2017 Feb;27(2):138-146. doi: 10.1016/j.numecd.2016.11.124. Epub 2016 Dec 9.
Preliminary findings indicate that consumption of Salba-chia (Salvia hispanica L.), an ancient seed, improves management of type 2 diabetes and suppresses appetite. The aim of this study was to assesse the effect of Salba-chia on body weight, visceral obesity and obesity-related risk factors in overweight and obese adults with type 2 diabetes.
A double-blind, randomized, controlled trial with two parallel groups involved 77 overweight or obese patients with type 2 diabetes (HbA: 6.5-8.0%; BMI: 25-40 kg/m). Both groups followed a 6-month calorie-restricted diet; one group received 30 g/1000 kcal/day of Salba-chia, the other 36 g/1000 kcal/day of an oat bran-based control. Primary endpoint was change in body weight over 6-months. Secondary endpoints included changes in waist circumference, body composition, glycemic control, C-reactive protein, and obesity-related satiety hormones.
At 6-months, participants on Salba-chia had lost more weight than those on control (1.9 ± 0.5 kg and 0.3 ± 0.4 kg, respectively; P = 0.020), accompanied by a greater reduction in waist circumference (3.5 ± 0.7 cm and 1.1 ± 0.7 cm, respectively; P = 0.027). C-reactive protein was reduced by 1.1 ± 0.5 mg/L (39 ± 17%) on Salba-chia, compared to 0.2 ± 0.4 mg/L (7 ± 20%) on control (P = 0.045). Plasma adiponectin on the test intervention increased by 6.5 ± 0.7%, with no change observed on control (P = 0.022).
The results of this study, support the beneficial role of Salba-chia seeds in promoting weight loss and improvements of obesity related risk factors, while maintaining good glycemic control. Supplementation of Salba-chia may be a useful dietary addition to conventional therapy in the management of obesity in diabetes. REGISTRATION: clinicaltrials.gov identifier: NCT01403571.
初步研究结果表明，食用古老的奇亚籽（芡欧鼠尾草）可改善2型糖尿病的管理并抑制食欲。本研究的目的是评估奇亚籽对超重和肥胖的2型糖尿病成年人的体重、内脏肥胖及肥胖相关危险因素的影响。
一项双盲、随机、平行对照试验纳入了77例超重或肥胖的2型糖尿病患者（糖化血红蛋白：6.5 - 8.0%；体重指数：25 - 40kg/m²）。两组均遵循为期6个月的热量限制饮食；一组每天每1000千卡摄入30克奇亚籽，另一组每天每1000千卡摄入36克燕麦麸作为对照。主要终点是6个月内体重的变化。次要终点包括腰围、身体成分、血糖控制、C反应蛋白及肥胖相关饱腹感激素的变化。
6个月时，食用奇亚籽的参与者比对照组体重减轻更多（分别为1.9±0.5千克和0.3±0.4千克；P = 0.020），腰围减少幅度更大（分别为3.5±0.7厘米和1.1±0.7厘米；P = 0.027）。奇亚籽组C反应蛋白降低了1.1±0.5毫克/升（39±17%），而对照组降低了0.2±0.4毫克/升（7±20%）（P = 0.045）。试验干预组血浆脂联素增加了6.5±0.7%，对照组无变化（P = 0.022）。
本研究结果支持奇亚籽在促进体重减轻和改善肥胖相关危险因素方面的有益作用，同时维持良好的血糖控制。在糖尿病肥胖管理中，补充奇亚籽可能是传统治疗中一种有用的饮食补充。注册信息：clinicaltrials.gov标识符：NCT01403571。
