Ohno Koichi, Okada Toshihiro, Nakamura Toshitsugu, Koyama Hiroshi
Department of Breast and Endocrine Surgery, Suwa Red Cross Hospital, 5-11-50, Kogan-douri, Suwa, Nagano, 392-8510, Japan.
Department of Diagnostic Pathology, Suwa Red Cross Hospital, 5-11-50, Kogan-douri, Suwa, Nagano, 392-8510, Japan.
Surg Case Rep. 2020 Feb 24;6(1):41. doi: 10.1186/s40792-020-0799-y.
Sebaceous carcinoma (SC) is frequently classified as periocular or extraocular. Extraocular SC is rare and mainly occurs in the head and neck, the major salivary glands, or oral mucosa. SC of the breast, lung, and ovary is particularly rare, and the few cases of SC of the breast predominantly exhibit intraductal growth.
A 47-year-old Japanese woman was referred to our hospital with accumulated polymorphic calcification in the left breast which was detected using mammography. Ultrasonography revealed an irregular 13-mm mass in the left breast, and analysis of a core needle biopsy revealed noninvasive ductal carcinoma. Total mastectomy and sentinel lymph node biopsy were performed. Histopathology demonstrated that carcinoma in situ (CIS) represented a significant lesion, and the cytoplasm of tumor cells was clear with numerous minute vacuoles. Immunohistochemical analysis demonstrated that most tumor cells expressed adipophilin. Together, these findings led to a diagnosis of SC, mainly comprising CIS.
We encountered a rare case of SC of the breast with predominant CIS.
皮脂腺癌（SC）通常分为眼周型或眼外型。眼外型皮脂腺癌较为罕见，主要发生于头颈部、主要唾液腺或口腔黏膜。乳腺、肺和卵巢的皮脂腺癌尤为罕见，乳腺皮脂腺癌的少数病例主要表现为导管内生长。
一名47岁的日本女性因乳腺钼靶检查发现左乳有多处多形性钙化而转诊至我院。超声检查发现左乳有一个不规则的13毫米肿块，粗针穿刺活检分析显示为非浸润性导管癌。遂行全乳切除术和前哨淋巴结活检。组织病理学显示原位癌（CIS）为主要病变，肿瘤细胞的细胞质清晰，有许多微小空泡。免疫组化分析显示大多数肿瘤细胞表达亲脂素。综合这些发现诊断为主要由原位癌构成的乳腺皮脂腺癌。
我们遇到了一例以原位癌为主的罕见乳腺皮脂腺癌病例。
