Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Neuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
J Neurooncol. 2020 Apr;147(2):397-404. doi: 10.1007/s11060-020-03433-8. Epub 2020 Feb 24.
Body image (BI) is an important issue for cancer patients, as patients with BI concerns are susceptible to depression, anxiety, difficulty coping, and poor quality of life (QoL). While this concern has been documented in patients with other malignancies, no data exists of this QoL issue in patients with primary brain tumors (PBT).
A cross-sectional survey of 100 PBT patients was conducted on an IRB approved prospective protocol using structured questionnaires. Participants completed the body image scale (BIS), Appearance Scheme Inventory Revised (ASI-R), MD Anderson Symptom Inventory Brain Tumor (MDASI-BT), and Patient-Reported Outcomes Measurement Information System (PROMIS) Depression, Anxiety, and Psychosocial Impact Positive measures.
The prevalence of clinically significant body image dissatisfaction (BIS ≥ 10) was 28% (95% CI 19-37%), median BIS score was 5 (range 0-27). The median ASI-R composite score was 2.9 (range 1.5-4.7). BIS was significantly correlated with the ASI-R (r = 0.53, 95% CI 0.37 to 0.65). The mean PROMIS Depression score was 48.4 (SD = 8.9), PROMIS Anxiety score was 49.4 (SD = 9.9), and PROMIS Psychosocial Illness Impact Positive score was 48.9 (SD = 9.7). BIS was significantly correlated with age, and trended with BMI and sex. The PROMIS Psychosocial Illness Impact Positive and PROMIS Anxiety scores were the most strongly related to BIS.
This study, the first to explore altered body image in PBT patients, revealed clinically significant body image dissatisfaction in nearly 1/3 of patients, similar to other malignancies. These findings underscore the potential contribution of disease and treatment-related body image concerns on psychosocial wellbeing in patients with PBT.
体像（BI）是癌症患者的一个重要问题，因为体像问题患者易患抑郁、焦虑、难以应对和生活质量（QoL）差。虽然在其他恶性肿瘤患者中已经记录到了这种担忧，但在原发性脑肿瘤（PBT）患者中，没有关于这种 QoL 问题的数据。
在一项经机构审查委员会批准的前瞻性协议下，对 100 名 PBT 患者进行了横断面调查，使用结构化问卷进行调查。参与者完成了体像量表（BIS）、外观量表修订版（ASI-R）、MD 安德森症状量表脑肿瘤（MDASI-BT）和患者报告的结果测量信息系统（PROMIS）抑郁、焦虑和心理社会影响积极措施。
临床上显著的体像不满意（BIS≥10）的患病率为 28%（95%CI 19-37%），BIS 中位数为 5（范围 0-27）。ASI-R 综合评分的中位数为 2.9（范围 1.5-4.7）。BIS 与 ASI-R 显著相关（r=0.53，95%CI 0.37-0.65）。PROMIS 抑郁评分的平均值为 48.4（SD=8.9），PROMIS 焦虑评分均为 49.4（SD=9.9），PROMIS 心理社会疾病影响积极评分均为 48.9（SD=9.7）。BIS 与年龄显著相关，与 BMI 和性别呈趋势相关。PROMIS 心理社会疾病影响积极评分和 PROMIS 焦虑评分与 BIS 最相关。
这项研究首次探讨了 PBT 患者的体像改变，结果显示近 1/3 的患者存在临床上显著的体像不满意，与其他恶性肿瘤相似。这些发现强调了疾病和治疗相关的体像问题对 PBT 患者心理社会健康的潜在影响。
