department of pediatrics and public health, university of turin, italy.
.
Med Lav. 2020 Feb 24;111(1):63-73. doi: 10.23749/mdl.v111i1.8967.
We carried out a systematic review and meta-analysis of epidemiologic studies on the association between occupational exposure to glyphosate and risk of non-Hodgkin lymphoma (NHL) and multiple myeloma (MM).
We conducted a systematic search of the literature, and identified 18 relevant publications, from which we extracted results from seven non-overlapping studies of NHL and three of MM. We performed random-effects meta-analyses for ever-exposure to glyphosate, dose-response, and risk of specific NHL subtypes.
The meta-relative risk (RR) of NHL was 1.03 (95% confidence interval [CI] 0.86-1.21), that of MM was 1.04 (95% CI 0.67-1.41). The meta-RR of NHL for highest category of exposure was 1.49 (95% CI 0.37-2.61; 3 studies). The meta-RR for diffuse large B-cell lymphoma (DLBCL) was 1.31 (95% CI 0.93-1.75); that for follicular lymphoma was 0.82 (95% CI 0.93-1.70), and that for chronic lymphocytic leukemia was 0.85 (95% CI 0.20-1.49). There was indication of publication bias for studies on NHL.
Our meta-analysis provided no overall evidence of an increased risk for both NHL and MM in subjects occupationally exposed to glyphosate. In secondary analyses we detected a small increase in risk for the category with highest level of exposure as well as for DLBCL. The evidence of publication bias suggests caution in the interpretation of the results.
我们对职业性接触草甘膦与非霍奇金淋巴瘤（NHL）和多发性骨髓瘤（MM）风险之间关联的流行病学研究进行了系统回顾和荟萃分析。
我们对文献进行了系统检索，从中提取了来自 7 项 NHL 研究和 3 项 MM 研究中不重叠的结果。我们对草甘膦的总暴露、剂量-反应和特定 NHL 亚型的风险进行了随机效应荟萃分析。
NHL 的荟萃相对风险（RR）为 1.03（95%置信区间 [CI] 0.86-1.21），MM 的 RR 为 1.04（95% CI 0.67-1.41）。最高暴露组的 NHL 荟萃 RR 为 1.49（95% CI 0.37-2.61；3 项研究）。弥漫性大 B 细胞淋巴瘤（DLBCL）的荟萃 RR 为 1.31（95% CI 0.93-1.75）；滤泡性淋巴瘤为 0.82（95% CI 0.93-1.70），慢性淋巴细胞白血病为 0.85（95% CI 0.20-1.49）。NHL 研究存在发表偏倚的迹象。
我们的荟萃分析没有提供总体证据表明职业性接触草甘膦会增加 NHL 和 MM 的风险。在二次分析中，我们发现最高暴露组的风险略有增加，DLBCL 也是如此。发表偏倚的证据表明，对结果的解释应谨慎。
