染色体分离：进化出具有可塑性的染色体-微管界面。

Chromosome Segregation: Evolving a Plastic Chromosome-Microtubule Interface.

机构信息

Whitehead Institute for Biomedical Research, and Department of Biology, Massachusetts Institute of Technology, 455 Main Street, Cambridge, MA 02142, USA.

出版信息

Curr Biol. 2020 Feb 24;30(4):R174-R177. doi: 10.1016/j.cub.2019.12.058.

DOI:10.1016/j.cub.2019.12.058

PMID:32097646

Abstract

Despite a conserved requirement in mediating chromosome segregation, kinetochores display remarkable plasticity in their structure and composition. New work in holocentric insect species highlights the molecular rewiring that occurs when key structural components of the kinetochore are lost and centromere structure is changed.

摘要

尽管在介导染色体分离方面存在保守需求，但着丝粒在结构和组成上表现出显著的可塑性。在具有全着丝粒的昆虫物种中的新工作强调了当着丝粒的关键结构成分丢失和着丝粒结构发生变化时发生的分子重布线。