氧化蛋白质聚集体：形成与生物学效应

Oxidized protein aggregates: Formation and biological effects.

作者信息

Grune Tilman

机构信息

Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany; German Center for Diabetes Research (DZD), 85764, Muenchen-Neuherberg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Berlin, 10785, Berlin, Germany; University of Potsdam, Institute of Nutritional Science, 14558, Nuthetal, Germany.

出版信息

Free Radic Biol Med. 2020 Apr;150:120-124. doi: 10.1016/j.freeradbiomed.2020.02.014. Epub 2020 Feb 22.

DOI:10.1016/j.freeradbiomed.2020.02.014

PMID:32097679

Abstract

The study of protein aggregates has a long history. While in the first decades until the 80ies of the 20th century only the observation of the presence of such aggregates was reported, later the biochemistry of the formation and the biological effects of theses aggregates were described. This review focusses on the complexity of the biological effects of protein aggregates and its potential role in the aging process.

摘要

蛋白质聚集体的研究有着悠久的历史。在20世纪80年代之前的几十年里，仅报道了对这类聚集体存在情况的观察，后来才描述了这些聚集体形成的生物化学过程及其生物学效应。这篇综述聚焦于蛋白质聚集体生物学效应的复杂性及其在衰老过程中的潜在作用。