Vasilevskaya Anna, Taghdiri Foad, Burke Charles, Tarazi Apameh, Naeimi Seyed Ali, Khodadadi Mozghan, Goswami Ruma, Sato Christine, Grinberg Mark, Moreno Danielle, Wennberg Richard, Mikulis David, Green Robin, Colella Brenda, Davis Karen D, Rusjan Pablo, Houle Sylvain, Tator Charles, Rogaeva Ekaterina, Tartaglia Maria C
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 60 Leonard avenue, Toronto, ON M5T 0S8, Canada; Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada; Division of Neurology, Toronto Western Hospital, University Health Network, 399 Bathurst St., Toronto, ON, M5T 2S8, Canada; Canadian Concussion Center, Toronto Western Hospital, Krembil Neuroscience Centre, University Health Network, 399 Bathurst St., Toronto, ON, M5T 2S8, Canada.
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 60 Leonard avenue, Toronto, ON M5T 0S8, Canada; Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada; Canadian Concussion Center, Toronto Western Hospital, Krembil Neuroscience Centre, University Health Network, 399 Bathurst St., Toronto, ON, M5T 2S8, Canada.
Neuroimage Clin. 2020;26:102212. doi: 10.1016/j.nicl.2020.102212. Epub 2020 Feb 13.
Genetic polymorphisms like apolipoprotein E (APOE) and microtubule-associated protein tau (MAPT) genes increase the risk of neurodegeneration.
38 former players (age 52.63±14.02) of contact sports underwent neuroimaging, biofluid collection, and comprehensive neuropsychological assessment. The [F-18]AV-1451 tracer signal was compared in the cortical grey matter between APOE4 allele carriers and non-carriers as well as carriers of MAPT H1H1 vs non-H1H1. Participants were then divided into the high (N = 13) and low (N = 13) groups based on cortical PET tau standard uptake value ratios (SUVRs) for comparison.
Cortical grey matter PET tau SUVR values were significantly higher in APOE4 carriers compared to non-carriers (p = 0.020). In contrast, there was no significant difference in SUVR between MAPT H1H1 vs non-H1H1 carrier genes (p = 1.00). There was a significantly higher APOE4 allele frequency in the high cortical grey matter PET tau group, comparing to low cortical grey matter PET tau group (p = 0.048). No significant difference in neuropsychological function was found between APOE4 allele carriers and non-carriers.
There is an association between higher cortical grey matter tau burden as seen with [F-18]AV-1451 PET tracer SUVR, and the APOE4 allele in former professional and semi-professional players at high risk of concussions. APOE4 allele may be a risk factor for tau accumulation in former contact sports athletes at high risk of neurodegeneration.
Toronto General and Western Hospital Foundations; Weston Brain Institute; Canadian Consortium on Neurodegeneration in ageing; Krembil Research Institute. There was no role of the funders in this study.
载脂蛋白E（APOE）和微管相关蛋白tau（MAPT）基因等基因多态性会增加神经退行性变的风险。
38名曾从事接触性运动的运动员（年龄52.63±14.02岁）接受了神经影像学检查、生物样本采集和全面的神经心理学评估。比较了APOE4等位基因携带者与非携带者以及MAPT H1H1携带者与非H1H1携带者之间皮质灰质中[F-18]AV-1451示踪剂信号。然后根据皮质PET tau标准摄取值比率（SUVRs）将参与者分为高（N = 13）低（N = 13）两组进行比较。
与非携带者相比，APOE4携带者的皮质灰质PET tau SUVR值显著更高（p = 0.020）。相比之下，MAPT H1H1与非H1H1携带者基因之间的SUVR无显著差异（p = 1.00）。皮质灰质PET tau高组的APOE4等位基因频率显著高于皮质灰质PET tau低组（p = 0.048）。APOE4等位基因携带者与非携带者之间的神经心理功能无显著差异。
在有脑震荡高风险的前职业和半职业运动员中，[F-18]AV-1451 PET示踪剂SUVR所显示的较高皮质灰质tau负荷与APOE4等位基因之间存在关联。APOE4等位基因可能是有神经退行性变高风险的前接触性运动运动员中tau积累的一个危险因素。
多伦多综合与西部医院基金会；韦斯顿脑研究所；加拿大衰老神经退行性变协会；克雷姆比尔研究所。资助者在本研究中未发挥任何作用。
