Department of Gastroenterology and Hepatology, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
Liver Research Center, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
Int J Mol Sci. 2020 Feb 21;21(4):1491. doi: 10.3390/ijms21041491.
Members of the polypeptide -acetylgalactosaminyltransferase (GALNT) family function as the initiating enzymes that catalyze mucin-type O-glycosylation of proteins, and their dysregulated expression can alter cancer cell behaviors such as de novo occurrence, proliferation, migration, metastasis, and drug resistance. Recent studies have demonstrated that one of the family's members, GALNT14, is aberrantly expressed in multiple cancers and involved in a variety of biological functions. Moreover, the single nucleotide polymorphisms (SNPs) of -rs9679162 have been shown to predict therapeutic outcomes in patients with hepatocellular carcinoma as well as several other different types of gastrointestinal cancer. This review summarizes the structural features of GANLT14, its functional roles, and the predictive values of genotypes and enzyme levels in multiple cancers receiving distinct anticancer therapies.
多肽-N-乙酰氨基半乳糖转移酶（GALNT）家族的成员作为起始酶，催化蛋白质的粘蛋白型 O-糖基化，其表达失调会改变癌细胞的行为，如新生、增殖、迁移、转移和耐药性。最近的研究表明，该家族的一个成员 GALNT14 在多种癌症中异常表达，并参与多种生物学功能。此外，-rs9679162 的单核苷酸多态性（SNP）已被证明可以预测肝癌以及其他几种不同类型的胃肠道癌症患者的治疗结果。这篇综述总结了 GALNT14 的结构特征、功能作用，以及在接受不同抗癌治疗的多种癌症中基因型和酶水平的预测价值。
