Kim Hyung Seok
Department of Biochemistry, Kosin University College of Medicine, Seo-gu, Busan, 49267, Republic of Korea.
Oncol Res. 2025 Apr 18;33(5):995-1000. doi: 10.32604/or.2025.060616. eCollection 2025.
The discovery of glycosylated RNA molecules, known as glycoRNAs, introduces a novel dimension to cellular biology. This commentary explores the transformative findings surrounding glycoRNAs, emphasizing their unique roles in cancer progression and the therapeutic opportunities they present. GlycoRNAs, through interactions with lectins and immune receptors, may contribute to tumor immune evasion. Moreover, the therapeutic potential of this emerging knowledge includes interventions targeting glycoRNA synthesis and modulation of associated signaling pathways. By highlighting these critical insights, this commentary aims to encourage the development of innovative strategies that could improve cancer prognosis and treatment.
糖基化RNA分子（即糖基化核糖核酸，glycoRNAs）的发现为细胞生物学引入了一个全新的维度。本评论探讨了围绕糖基化核糖核酸的变革性发现，强调了它们在癌症进展中的独特作用以及所带来的治疗机会。糖基化核糖核酸通过与凝集素和免疫受体相互作用，可能有助于肿瘤免疫逃逸。此外，这一新兴知识的治疗潜力包括针对糖基化核糖核酸合成的干预措施以及对相关信号通路的调节。通过突出这些关键见解，本评论旨在鼓励开发能够改善癌症预后和治疗效果的创新策略。
