人乳头瘤病毒相关头颈部鳞状细胞癌的分子诊断。
Molecular Diagnostics in Human Papillomavirus-Related Head and Neck Squamous Cell Carcinoma.
机构信息
Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, CA 94158, USA.
Department of Pathology, University of California San Francisco, San Francisco, CA 94158, USA.
出版信息
Cells. 2020 Feb 22;9(2):500. doi: 10.3390/cells9020500.
The incidence of human papillomavirus (HPV)-related head and neck squamous cell carcinoma continues to increase. Accurate diagnosis of the HPV status of a tumor is vital, as HPV+ versus HPV- tumors represent two unique biological and clinical entities with different treatment strategies. High-risk HPV subtypes encode oncoproteins E6 and E7 that disrupt cellular senescence and ultimately drive tumorigenesis. Current methods for detection of HPV take advantage of this established oncogenic pathway and detect HPV at various biological stages. This review article provides an overview of the existing technologies employed for the detection of HPV and their current or potential future role in management and prognostication.
人乳头瘤病毒（HPV）相关的头颈部鳞状细胞癌的发病率持续上升。准确诊断肿瘤的 HPV 状态至关重要，因为 HPV+与 HPV-肿瘤代表两种具有不同治疗策略的独特生物学和临床实体。高危型 HPV 亚型编码致癌蛋白 E6 和 E7，破坏细胞衰老，最终导致肿瘤发生。目前检测 HPV 的方法利用了这一已确立的致癌途径，并在各种生物学阶段检测 HPV。本文综述了目前用于 HPV 检测的技术及其在管理和预后中的当前或潜在未来作用。
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