Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russian.
Department of Biochemistry, Sechenov First Moscow State Medical University, 119991 Moscow, Russian.
Cells. 2020 Feb 22;9(2):503. doi: 10.3390/cells9020503.
The main purpose of the review article is to assess the contributions of telomere length and telomerase activity to the cardiac function at different stages of development and clarify their role in cardiac disorders. It has been shown that the telomerase complex and telomeres are of great importance in many periods of ontogenesis due to the regulation of the proliferative capacity of heart cells. The review article also discusses the problems of heart regeneration and the identification of possible causes of dysfunction of telomeres and telomerase.
这篇综述文章的主要目的是评估端粒长度和端粒酶活性在不同发育阶段对心脏功能的贡献，并阐明它们在心脏疾病中的作用。已经表明，端粒酶复合物和端粒在许多胚胎发生时期都非常重要，因为它们调节心脏细胞的增殖能力。这篇综述文章还讨论了心脏再生的问题，以及鉴定端粒和端粒酶功能障碍的可能原因。
