Department of Physiology, School of Medicine, University of Puerto Rico, San Juan, PR 00936-5067, USA.
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, 1200 Vienna, Austria.
Cells. 2020 May 9;9(5):1177. doi: 10.3390/cells9051177.
Mitochondria are subcellular organelles evolved by endosymbiosis of bacteria with eukaryotic cells characteristics. They are the main source of ATP in the cell and play a pivotal role in cell life and cell death. Mitochondria are engaged in the pathogenesis of human diseases and aging directly or indirectly through a broad range of signaling pathways. However, despite an increased interest in mitochondria over the past decades, the mechanisms of mitochondria-mediated cell/organ dysfunction in response to pathological stimuli remain unknown. The Special Issue, "Mitochondria in Health and Diseases," organized by includes 24 review and original articles that highlight the latest achievements in elucidating the role of mitochondria under physiological (healthy) conditions and, in various cell/animal models of human diseases and, in patients. Altogether, the Special Issue summarizes and discusses different aspects of mitochondrial metabolism and function that open new avenues in understanding mitochondrial biology.
线粒体是由真核细胞特征的细菌内共生进化而来的亚细胞细胞器。它们是细胞中 ATP 的主要来源，在细胞生命和细胞死亡中起着关键作用。线粒体通过广泛的信号通路直接或间接地参与人类疾病和衰老的发病机制。然而，尽管过去几十年来人们对线粒体的兴趣增加，但对于线粒体介导的细胞/器官功能障碍对病理刺激的反应机制仍不清楚。本专题由 组织，包括 24 篇综述和原创文章，重点阐述了在阐明生理（健康）条件下线粒体的作用以及在各种人类疾病的细胞/动物模型中和患者中的最新成果。总的来说，本专题总结和讨论了线粒体代谢和功能的不同方面，为理解线粒体生物学开辟了新的途径。
