Department of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, P.R. China.
Center for Information in Biology, University of Electronic Science and Technology of China, Chengdu Sichuan, P.R. China.
Expert Opin Drug Deliv. 2020 May;17(5):725-733. doi: 10.1080/17425247.2020.1736033. Epub 2020 Mar 3.
: Mesoporous silica nanoparticles (MSNs) with unique advantages can combine multiple functionalities including imaging and therapeutic into one single platform that can provide personalized diagnosis and treatment. In this study, we fabricated a multifunctional nanocomplex for the delivery of a classic chemotherapy drug (Doxorubicin, DOX) and a near-infrared (NIR) dye (indocyanine green, ICG) based on mesoporous silica-coated FeO nanoparticles. Hyaluronic acid (HA) was conjugated onto the surface of the nanocomplex to respond to hyaluronidase (HAase). the final complex is short for M-MSN/HA/DI.: The successful synthesis of M-MSN-HA/DI nanocomplex was confirmed by Fourier transform infrared spectroscopy and UV-vis spectrometer. The photothermal conversion efficiency and antitumor efficiency in breast cancer bearing mice were further evaluated.: M-MSN/HA/DI showed preeminent T MR and fluorescence (FL) imaging ability, and the release of DOX was accelerated in the presence of HAase. The nanocomplex generated high heat upon 808 nm NIR irradiation and efficiently induced apoptosis in breast cancer cells. The studies demonstrated that the final nanocomplex can inhibit tumor growth with minimal systemic toxicity upon 808 nm NIR irradiation.: Collectively, our work offers a preclinical proof of concept for a multifunctional drug delivery system for cancer therapy and imaging,which could achieve efficient application for cancer.
介孔硅纳米粒子（MSNs）具有独特的优势，可将多种功能（包括成像和治疗）结合到一个单一的平台中，为患者提供个性化的诊断和治疗。在本研究中，我们制备了一种基于介孔硅包覆的 FeO 纳米粒子的多功能纳米复合物，用于递送经典化疗药物（阿霉素，DOX）和近红外（NIR）染料（吲哚菁绿，ICG）。透明质酸（HA）被接枝到纳米复合物的表面以响应透明质酸酶（HAase）。最终的复合物简称 M-MSN/HA/DI。通过傅里叶变换红外光谱和紫外-可见分光光度计证实了 M-MSN-HA/DI 纳米复合物的成功合成。进一步在荷乳腺癌小鼠中评估了其光热转换效率和抗肿瘤效率。M-MSN/HA/DI 表现出卓越的 T1 磁共振和荧光（FL）成像能力，并且在 HAase 的存在下加速了 DOX 的释放。该纳米复合物在 808nm NIR 照射下产生高热，并有效诱导乳腺癌细胞凋亡。这些研究表明，最终的纳米复合物可以在 808nm NIR 照射下抑制肿瘤生长，同时具有最小的全身毒性。总之，我们的工作为癌症治疗和成像的多功能药物递送系统提供了临床前概念验证，有望实现癌症的高效应用。
