Department of Pharmacy, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
Nanomedicine (Lond). 2020 Mar;15(6):603-624. doi: 10.2217/nnm-2019-0385. Epub 2020 Feb 26.
To formulate and evaluate a pH-responsive nanoparticle (NP)-based patch for efficient transdermal delivery of flurbiprofen against rheumatoid arthritis. Nanoprecipitation technique was used for preparation of NPs and central composite design was employed for optimization purposes. Optimized NPs were loaded into the transdermal patch by the solvent evaporation method. Prepared NPs exhibited an average size of 69 nm, while NPs loaded onto the transdermal patch showed sustained release and high permeation through the skin. In studies, the prepared carrier system elucidated high therapeutic potential in both acute and chronic inflammatory models as evident from the results of behavioral, radiological, histopathological and antioxidant analyses. The flurbiprofen-loaded pH-sensitive NP-based transdermal patch has the potential to manage rheumatoid arthritis effectively.
为了研制和评估一种 pH 响应型纳米粒子（NP）贴片，以高效透皮递氟比洛芬治疗类风湿关节炎。采用纳米沉淀技术制备 NPs，并采用中心复合设计进行优化。通过溶剂蒸发法将优化后的 NPs 载入透皮贴剂中。所制备的 NPs 的平均粒径为 69nm，而负载在透皮贴剂上的 NPs 表现出持续释放和高透过皮肤的效果。在研究中，所制备的载体系统在急性和慢性炎症模型中表现出了高的治疗潜力，这从行为学、影像学、组织病理学和抗氧化分析的结果中可以明显看出。载氟比洛芬的 pH 敏感型 NP 基透皮贴剂具有有效治疗类风湿关节炎的潜力。
