Stichting HIV Monitoring, Amsterdam, the Netherlands.
National Institute for Public Health and the Environment (RIVM); Centre for Infectious Disease Control, Epidemiology and Surveillance, Bilthoven, the Netherlands.
Euro Surveill. 2020 Feb;25(7). doi: 10.2807/1560-7917.ES.2020.25.7.1900450.
BackgroundWith regards to the global strategy towards eliminating viral hepatitis, reliable surveillance systems are essential to assess the national response for eliminating hepatitis C virus (HCV).AimWe aimed to assess the completeness of the two national registries with data on acute HCV infection in people with HIV, and estimated the number of acute HCV infections among adults (aged ≥ 18 years) with HIV in the Netherlands.MethodsIn this observational study, cases of HCV infection and reinfection among adults with a positive or unknown HIV-serostatus were identified from 2003 to 2016 in two national registries: the ATHENA cohort and the National Registry for Notifiable Diseases. For 2013-2016, cases were linked, and two-way capture-recapture analysis was carried out.ResultsDuring 2013-2016, there were an estimated 282 (95% confidence interval (CI): 264-301) acute HCV infections among adults with HIV. The addition of cases with an unknown HIV-serostatus increased the matches (from n = 107 to n = 129), and subsequently increased the estimated total: 330 (95%CI: 309-351). Under-reporting was estimated at 14-20%.ConclusionUnder-reporting of acute HCV infection among people with HIV could partially be explained by an unknown HIV-serostatus, or by differences in HCV stage (acute or chronic) at first diagnosis. Surveillance data should ideally include both acute and chronic HCV infections, and enable to distinguish these as well as initial- and re-infections. National surveillance of acute HCV can be improved by increased notification of infections.
就全球消除病毒性肝炎战略而言，可靠的监测系统对于评估消除丙型肝炎病毒（HCV）的国家应对措施至关重要。
我们旨在评估两个国家登记处中关于 HIV 感染者急性 HCV 感染数据的完整性，并估计荷兰 HIV 成年感染者（年龄≥18 岁）中的急性 HCV 感染人数。
在这项观察性研究中，从 2003 年至 2016 年，从两个国家登记处（ATHENA 队列和国家传染病登记处）中确定了 HIV 阳性或未知血清状态的成年人中 HCV 感染和再感染的病例。对于 2013-2016 年，进行了病例链接，并进行了双向捕获-再捕获分析。
2013-2016 年，估计有 282 例（95%置信区间（CI）：264-301）HIV 成年感染者发生急性 HCV 感染。增加未知 HIV 血清状态的病例数增加了匹配数（从 n=107 增加到 n=129），随后增加了估计总数：330（95%CI：309-351）。漏报率估计为 14-20%。
HIV 感染者中急性 HCV 感染的漏报部分可归因于未知的 HIV 血清状态，或首次诊断时 HCV 阶段（急性或慢性）的差异。监测数据最好同时包括急性和慢性 HCV 感染，并能够区分这些以及初次感染和再感染。通过增加对感染的报告，可以改善急性 HCV 的国家监测。
