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Sirtuin 5 deficiency increases disease severity in rats with adjuvant-induced arthritis.

作者信息

Zhang Ni, Zhang Hui, Law Betty Yuen Kwan, Dias Ivo Ricardo De Seabra Rodrigues, Qiu Cong Ling, Zeng Wu, Dan Pan Hu, Chen Jin Yun, Bai Yan Fu, Lv Jing, Qu Li Qun, Chen Xi, Huang Qi, Zhang Wei, Yang Li Jun, Yu Lu, Han Yu, Huang Guo Xin, Wang Hui Miao, Sun Xiao Lei, Zhang Yun, He Hu Qiang, Dan Luo Wei, Xiao Yao, Zhou Jian, Xu Ting, Huang Qing Chun, Wu Min, Huang Zhi Sheng, Liu Wei, Wong Vincent Kam Wai, Liu Liang

机构信息

State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, China.

The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.

出版信息

Cell Mol Immunol. 2020 Nov;17(11):1190-1192. doi: 10.1038/s41423-020-0380-4. Epub 2020 Feb 25.

DOI:10.1038/s41423-020-0380-4
PMID:32099074
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7784877/
Abstract
摘要

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本文引用的文献

1
Ethyl pyruvate ameliorates inflammatory arthritis in mice.丙酮酸乙酯改善小鼠炎症性关节炎。
Int Immunopharmacol. 2017 Nov;52:333-341. doi: 10.1016/j.intimp.2017.09.027. Epub 2017 Oct 6.
2
SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1β Production and to Prevent DSS-Induced Colitis in Mice.SIRT5去琥珀酰化并激活丙酮酸激酶M2，以阻断巨噬细胞白细胞介素-1β的产生，并预防小鼠中由葡聚糖硫酸钠诱导的结肠炎。
Cell Rep. 2017 Jun 13;19(11):2331-2344. doi: 10.1016/j.celrep.2017.05.065.
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NAD dependent deacetylase Sirtuin 5 rescues the innate inflammatory response of endotoxin tolerant macrophages by promoting acetylation of p65.NAD 依赖性去乙酰化酶 Sirtuin 5 通过促进 p65 的乙酰化来挽救内毒素耐受巨噬细胞的固有炎症反应。
J Autoimmun. 2017 Jul;81:120-129. doi: 10.1016/j.jaut.2017.04.006. Epub 2017 Apr 29.
4
Fructose 1,6-bisphosphate, a high-energy intermediate of glycolysis, attenuates experimental arthritis by activating anti-inflammatory adenosinergic pathway.1,6-二磷酸果糖是糖酵解的一种高能中间产物，它通过激活抗炎腺苷能途径减轻实验性关节炎。
Sci Rep. 2015 Oct 19;5:15171. doi: 10.1038/srep15171.
5
SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.SIRT5 调节线粒体赖氨酸琥珀酰化组和代谢网络。
Cell Metab. 2013 Dec 3;18(6):920-33. doi: 10.1016/j.cmet.2013.11.013.
6
SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance.SIRT1 在类风湿关节炎滑膜中的过度表达有助于促炎细胞因子的产生和抗细胞凋亡。
Ann Rheum Dis. 2011 Oct;70(10):1866-73. doi: 10.1136/ard.2010.148957. Epub 2011 Jul 8.
7
Regulation of cancer cell metabolism.癌细胞代谢的调控。
Nat Rev Cancer. 2011 Feb;11(2):85-95. doi: 10.1038/nrc2981.
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SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle.SIRT5使氨甲酰磷酸合成酶1去乙酰化并调节尿素循环。
Cell. 2009 May 1;137(3):560-70. doi: 10.1016/j.cell.2009.02.026.
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Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation.丙酮酸乙酯可预防已患致死性败血症和全身炎症的小鼠死亡。
Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12351-6. doi: 10.1073/pnas.192222999. Epub 2002 Sep 3.