Valery Patricia Casarolli, McWhirter William, Sleigh Adrian, Williams Gail, Bain Chris
Population & Clinical Sciences Division, Queensland Institute of Medical Research, Royal Brisbane Hospital, Australia.
Cancer Causes Control. 2002 Apr;13(3):263-70. doi: 10.1023/a:1015036109130.
It has been suggested that parental occupation, particularly farming, increased the risk of Ewing's sarcoma in the offspring. In a national case-control study we examined the relationship between farm and other parental occupational exposures and the risk of cancer in the offspring.
Cases were 106 persons with confirmed Ewing's sarcoma or peripheral primitive neuroectodermal tumor. Population-based controls (344) were selected randomly via telephone. Information was collected by interview (84% face-to-face).
We found an excess of case mothers who worked on farms at conception and/or pregnancy (odds ratio (OR)=2.3. 95% confidence interval (CI) 0.5-12.0) and a slightly smaller excess of farming fathers, more case mothers usually worked as laborers, machine operators, or drivers (OR = 1.8, 95% CI 0.9-3.9). Risk doubled for those whose mothers handled pesticides and insecticides, or fathers who handled solvents and glues, and oils and greases. Further, more cases lived on farms (OR= 1.6, 95% CI 0.9-2.8). In the 0-20 years group, the risk doubled for those who ever lived on a farm (OR = 2.0, 95% CI 1.0-3.9), and more than tripled for those with farming fathers at conception and/or pregnancy (OR = 3.5, 95% CI 1.0-1 1.9).
Our data support the general hypothesis of an association of Ewing's sarcoma family of tumors with farming, particularly at younger ages. who represent the bulk of cases, and are more likely to share etiologic factors.
有人提出父母的职业，尤其是务农，会增加子女患尤因肉瘤的风险。在一项全国性病例对照研究中，我们研究了农场及其他父母职业暴露与子女患癌风险之间的关系。
病例为106例确诊为尤因肉瘤或外周原始神经外胚层肿瘤的患者。通过电话随机选取以人群为基础的对照（344例）。通过访谈收集信息（84%为面对面访谈）。
我们发现，在受孕和/或怀孕期间从事农场工作的病例母亲比例过高（优势比（OR）=2.3，95%置信区间（CI）0.5 - 12.0），从事农场工作的病例父亲比例略低，更多病例母亲通常从事劳动者、机器操作员或司机工作（OR = 1.8，95% CI 0.9 - 3.9）。母亲接触农药和杀虫剂或父亲接触溶剂、胶水以及油和油脂的人群，其风险翻倍。此外，更多病例居住在农场（OR = 1.6，95% CI 0.9 - 2.8）。在0至20岁年龄组中，曾居住在农场的人群风险翻倍（OR = 2.0，95% CI 1.0 - 3.9），受孕和/或怀孕期间父亲从事农场工作的人群风险增加两倍多（OR = 3.5，95% CI 1.0 - 11.9）。
我们的数据支持尤因肉瘤家族性肿瘤与务农存在关联这一总体假设，尤其是在年龄较小的时候，这一年龄段代表了大部分病例，并且更有可能共享病因学因素。
