Section of Geriatric Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Italian National Research Center on Aging (INRCA), Ancona, Fermo and Cosenza, Italy.
Clin Interv Aging. 2020 Feb 4;15:133-140. doi: 10.2147/CIA.S239186. eCollection 2020.
Aortic stiffness (AS) is associated with cardiovascular events and all-cause mortality in the older population. AS might also influence the health-related quality of life (HRQOL) as a result of the negative effects of AS on cognitive and physical morbidity. We aimed to investigate the possible association between AS and HRQOL in people aged 75 years and over.
This cross-sectional study was part of the SCOPE study, an international multicenter cohort observational study. The indicators for AS were aortic pulse wave velocity (aPWV) and central pulse pressure (cPP). HRQOL was assessed using the EQ-5D index and the EQ-5D visual analog scale (VAS). ANCOVA and multivariate regression models were used to investigate possible associations.
We included 280 Dutch participants of the SCOPE study. Median age was 79 years (IQR 76-83) and 42.1% were women. Participants reporting any problem on the EQ-5D index (n=214) had higher values of aPWV (12.6 vs 12.2 m/s, p = 0.024) than participants not experiencing any problem (n=66) and comparable values of cPP (44.4 vs 42.0 mmHg, p = 0.119). Estimates only slightly changed after adjustments. No association was found between indicators of AS and EQ-5D VAS.
Aortic stiffness was associated with impaired quality of late life. This association could be mediated by subclinical vascular pathology affecting mental and physical health.
在老年人群中，主动脉僵硬（AS）与心血管事件和全因死亡率相关。由于 AS 对认知和身体发病率的负面影响，AS 也可能影响健康相关生活质量（HRQOL）。我们旨在研究 75 岁及以上人群中 AS 与 HRQOL 之间可能存在的关联。
这是一项横断面研究，是 SCOPE 研究的一部分，这是一项国际性多中心队列观察性研究。AS 的指标是主动脉脉搏波速度（aPWV）和中心脉搏压（cPP）。使用 EQ-5D 指数和 EQ-5D 视觉模拟量表（VAS）评估 HRQOL。使用协方差分析和多变量回归模型来研究可能的关联。
我们纳入了 SCOPE 研究的 280 名荷兰参与者。中位年龄为 79 岁（IQR 76-83），42.1%为女性。报告 EQ-5D 指数有任何问题的参与者（n=214）的 aPWV 值较高（12.6 比 12.2 m/s，p=0.024），而没有任何问题的参与者（n=66）的 cPP 值相当（44.4 比 42.0 mmHg，p=0.119）。调整后估计值略有变化。AS 指标与 EQ-5D VAS 之间没有关联。
主动脉僵硬与晚年生活质量受损有关。这种关联可能是由影响精神和身体健康的亚临床血管病理学介导的。
