接受伏立康唑预防治疗的异基因造血干细胞移植患者发生感染
Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient Receiving Voriconazole Prophylaxis.
作者信息
Agrawal Vaibhav, Brinda Bryan J, Farag Sherif S
机构信息
Department of Medicine, Division of Hematology and Oncology, Indiana University School of Medicine, Indianapolis, IN, USA.
Bone Marrow and Blood Stem Cell Transplantation Program, Indiana University, Indianapolis, IN, USA.
出版信息
Case Rep Hematol. 2020 Feb 12;2020:8124137. doi: 10.1155/2020/8124137. eCollection 2020.
Abstract
infection is a rare complication in the allogeneic stem cell transplant patients. Minimal guidance exists on how to appropriately manage histoplasmosis in these patients. We report a patient who developed pneumonia while receiving voriconazole prophylaxis at a therapeutic trough level. The patient experienced significant clinical improvement after initiation of itraconazole pharmacotherapy. We recommend a lower threshold for evaluation for histoplasmosis in allogeneic hematopoietic stem cell transplant recipients who live in endemic regions, regardless of their antifungal prophylactic regimen.
摘要
感染是异基因干细胞移植患者中罕见的并发症。对于如何恰当地处理这些患者的组织胞浆菌病，现有的指导意见很少。我们报告了一名在接受伏立康唑预防治疗且血药谷浓度处于治疗水平时发生肺炎的患者。在开始伊曲康唑药物治疗后，该患者的临床症状有了显著改善。我们建议，对于生活在流行地区的异基因造血干细胞移植受者，无论其抗真菌预防方案如何，都应降低对组织胞浆菌病的评估阈值。
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