Division of Infectious Diseases, Department of Medicine, City of Hope National Medical Center, Duarte, CA 91010, USA.
Department of Pharmacy Services, City of Hope National Medical Center, Duarte, CA 91010, USA.
Viruses. 2024 Sep 30;16(10):1560. doi: 10.3390/v16101560.
Hematopoietic stem cell transplant (HSCT) is now recognized as a standard treatment option for people with HIV (PWH) who develop high-risk hematologic malignancies. However, the involved polypharmacy can lead to complications from drug interactions and toxicities, affecting the efficacy and safety of chemotherapy and antiretroviral therapy (ART). Managing these patients requires a personalized approach, including the careful selection of ART based on previous therapies and potential interactions, alongside risk assessment for infections. This discussion will address the history of HSCT in PWH and management considerations for this group.
造血干细胞移植（HSCT）现在被认为是患有高危血液系统恶性肿瘤的 HIV（艾滋病毒）感染者的标准治疗选择。然而，涉及的多种药物治疗可能导致药物相互作用和毒性的并发症，从而影响化疗和抗逆转录病毒治疗（ART）的疗效和安全性。管理这些患者需要个性化的方法，包括根据以前的治疗和潜在的相互作用仔细选择 ART，同时对感染进行风险评估。本讨论将介绍 HSCT 在 HIV 感染者中的历史和对该人群的管理注意事项。
