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采用骨髓浓缩物和同种异体软骨细胞外基质增强的自体软骨移植

Autograft Cartilage Transfer Augmented With Bone Marrow Concentrate and Allograft Cartilage Extracellular Matrix.

作者信息

Lavender Chad, Sina Adil Syed Ali, Singh Vishavpreet, Berdis Galen

机构信息

Marshall University, Orthopaedic Surgery, Huntington, West Virginia, U.S.A.

出版信息

Arthrosc Tech. 2020 Jan 9;9(2):e199-e203. doi: 10.1016/j.eats.2019.09.022. eCollection 2020 Feb.

DOI:10.1016/j.eats.2019.09.022
PMID:32099772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7029053/
Abstract

The use of biologics in sports medicine is increasing rapidly. An osteochondral defect in a young active patient remains a difficult issue to treat. Autograft cartilage has tremendous advantages for the treatment of full-thickness defects, but harvesting and preparation have been difficult in the past. Disadvantages have included donor-site morbidity and the need for further surgery. With the recent development of the GraftNet device (Arthrex, Naples, FL), harvesting and delivery of autograft have become easier and can be performed arthroscopically in a single surgical procedure. Bone marrow concentrate has recently increased in popularity owing to the presence of mesenchymal stem cells. These stem cells combined with autograft cartilage and BioCartilage (Arthrex) could lead to better incorporation and healing. In this article, we show how this unique biological composite is obtained and then added in the cartilage defect during a single-stage arthroscopic procedure.

摘要

生物制剂在运动医学中的应用正在迅速增加。年轻活跃患者的骨软骨缺损仍然是一个难以治疗的问题。自体移植软骨在治疗全层缺损方面具有巨大优势，但过去采集和制备一直很困难。缺点包括供区发病以及需要进一步手术。随着GraftNet设备（Arthrex，那不勒斯，佛罗里达州）的最新发展，自体移植的采集和递送变得更加容易，并且可以在单一手术过程中通过关节镜进行。由于间充质干细胞的存在，骨髓浓缩物最近越来越受欢迎。这些干细胞与自体移植软骨和BioCartilage（Arthrex）相结合可能会导致更好的整合和愈合。在本文中，我们展示了如何获得这种独特的生物复合材料，然后在单阶段关节镜手术过程中将其添加到软骨缺损中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0374/7029053/19a5f76a141e/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0374/7029053/fff08669794b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0374/7029053/d01b0e2443ba/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0374/7029053/caf31a87a0f8/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0374/7029053/1da17efbd3f8/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0374/7029053/662ec76544e2/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0374/7029053/b92baa8cd785/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0374/7029053/a49b08e42230/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0374/7029053/f2beb58ad03d/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0374/7029053/35f74872f81a/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0374/7029053/19a5f76a141e/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0374/7029053/fff08669794b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0374/7029053/d01b0e2443ba/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0374/7029053/caf31a87a0f8/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0374/7029053/1da17efbd3f8/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0374/7029053/662ec76544e2/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0374/7029053/b92baa8cd785/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0374/7029053/a49b08e42230/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0374/7029053/f2beb58ad03d/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0374/7029053/35f74872f81a/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0374/7029053/19a5f76a141e/gr10.jpg

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