Sofic E, Paulus W, Jellinger K, Riederer P, Youdim M B
Clinical Neurochemistry, Department of Psychiatry, University of Würzburg, F.R.G.
J Neurochem. 1991 Mar;56(3):978-82. doi: 10.1111/j.1471-4159.1991.tb02017.x.
Histochemical and biochemical determinations of total iron, iron (II), and iron (III) contents in brain regions from Parkinson's and Alzheimer's diseases have demonstrated a selective increase of total iron content in parkinsonian substantia nigra zona compacta but not in the zona reticulata. The increase of iron content is mainly in iron (III). The ratio of iron (II):iron (III) in zona compacta changes from almost 2:1 to 1:2. This change is thought to be relevant and may contribute to the selective elevation of basal lipid peroxidation in substantia nigra reported previously. Iron may be available in a free state and thus can participate in autooxidation of dopamine with the resultant generation of H2O2 and oxygen free radicals.
对帕金森病和阿尔茨海默病患者脑区总铁、亚铁和铁含量进行的组织化学和生化测定表明，帕金森病患者黑质致密部总铁含量有选择性增加，而网状部则无。铁含量的增加主要是三价铁。致密部中亚铁与三价铁的比例从几乎2:1变为1:2。这种变化被认为是相关的，可能是之前报道的黑质中基础脂质过氧化选择性升高的原因。铁可能以游离状态存在，因此可以参与多巴胺的自动氧化，从而产生过氧化氢和氧自由基。
