Chiodi F, Sönnerborg A, Albert J, Gaines H, Norkrans G, Hagberg L, Asjö B, Strannegård O, Fenyö E M
Department of Virology, Karolinska Institute, Stockholm, Sweden.
J Neurol Sci. 1988 Jul;85(3):245-57. doi: 10.1016/0022-510x(88)90184-0.
Isolation of the human immunodeficiency virus (HIV) has been attempted from the cerebrospinal fluid (CSF) of 29 subjects with varying severity of HIV infection. Virus could be isolated from patients in all stages of disease including patients with primary HIV infection and asymptomatic carriers. In the early stages of infection free virus was infrequently present in the CSF but could be isolated from the cells present in CSF. This suggests that HIV may reach the brain at a very early stage of infection and that initially there is little production of virus from infected cells. In the late stages of HIV infection, associated with increasing severity of immunodeficiency, free virus could readily be isolated from the CSF. With one exception, all of these patients had neurological and/or psychiatric symptoms, as compared to only 2 (of 13) subjects in the early stages of infection. All patients with HIV-specific antibodies in serum had antibodies also in CSF. Examined by a radioimmunoprecipitation assay, CSF was more often found to contain antibodies to the precursor (p55) of viral core proteins than the corresponding serum of the patients. We propose that immune disturbances have an essential pathogenic role in the neurological/psychiatric symptoms associated with HIV infection, possibly through allowing increased viral expression in the central nervous system.
已尝试从29名感染程度各异的人类免疫缺陷病毒（HIV）感染者的脑脊液（CSF）中分离病毒。在疾病的各个阶段，包括原发性HIV感染患者和无症状携带者，均可从患者体内分离出病毒。在感染早期，脑脊液中很少出现游离病毒，但可从脑脊液中的细胞中分离出病毒。这表明HIV可能在感染的极早期就进入大脑，且最初受感染细胞产生的病毒很少。在HIV感染后期，随着免疫缺陷程度的加重，可轻易从脑脊液中分离出游离病毒。除1例例外，所有这些患者均有神经和/或精神症状，而在感染早期的患者中（13例中有2例）仅有此类症状。血清中具有HIV特异性抗体的所有患者，其脑脊液中也有抗体。通过放射免疫沉淀试验检测发现，脑脊液中比患者相应血清更常含有针对病毒核心蛋白前体（p55）的抗体。我们认为，免疫紊乱在与HIV感染相关的神经/精神症状中起重要致病作用，可能是通过使中枢神经系统中的病毒表达增加来实现的。
