School of Nursing, College of Nursing, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
School of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
Eur J Cancer Care (Engl). 2020 Jul;29(4):e13233. doi: 10.1111/ecc.13233. Epub 2020 Feb 25.
To explore the relationship of exercise timing (exercising close to bedtime, exercising in daylight and maintaining fixed exercise schedule) with sleep quality, fatigue and rest-activity rhythms among lung cancer patients in Taiwan.
Results from 43 lung cancer patients who were assigned and adhered to the exercise intervention in a 12-week randomised controlled trial were analysed. The MD Anderson Symptom Inventory and Pittsburgh Sleep Quality Index (PSQI) were administered. Actigraphs were used to assess rest-activity rhythms (in-bed less than out-of-bed dichotomy index, I < O) and objective sleep parameters, including total sleep time (TST) and sleep onset latency (SOL).
Patients who exercised >4 hr before bedtime had significant improvement in fatigue (p < .0001), sleep quality (p = .012 for PSQI; p = .037 for TST; p = .017 for SOL) and rest-activity rhythms (p = .048 for I < O). Furthermore, patients who exercised with daylight exposure had a significant improvement in fatigue (p = .037) and sleep quality (p = .039 for PSQI).
Exercising >4 hr before bedtime with daylight exposure is associated with improvement in rest-activity rhythms, sleep quality and fatigue in lung cancer patients. The causal relationship requires further investigation with experimental design.
探讨运动时间（接近就寝时间运动、在白天运动和保持固定运动时间表）与台湾肺癌患者的睡眠质量、疲劳和活动-休息节律之间的关系。
对参加为期 12 周的随机对照试验并接受运动干预的 43 例肺癌患者的结果进行分析。采用 MD 安德森症状量表和匹兹堡睡眠质量指数（PSQI）进行评估。使用活动记录仪评估活动-休息节律（卧床时间少于起床时间二分位数指数，I < O）和客观睡眠参数，包括总睡眠时间（TST）和睡眠潜伏期（SOL）。
在就寝时间前>4 小时进行运动的患者，疲劳（p<0.0001）、睡眠质量（PSQI：p=0.012；TST：p=0.037；SOL：p=0.017）和活动-休息节律（I < O：p=0.048）均有显著改善。此外，在白天有阳光照射时运动的患者，疲劳（p=0.037）和睡眠质量（PSQI：p=0.039）均有显著改善。
在白天有阳光照射时，在就寝时间前>4 小时进行运动与改善肺癌患者的活动-休息节律、睡眠质量和疲劳有关。因果关系需要进一步通过实验设计进行调查。
