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昼夜节律研究进展在癌症患者心理康复中的应用。

Research progress in circadian rhythms in the application of psychological rehabilitation of cancer patients.

机构信息

Department of Nursing, Third Xiangya Hospital, Central South University, Changsha 410013.

Xiangya Nursing School, Central South University, Changsha 410013.

出版信息

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2022 Dec 28;47(12):1740-1747. doi: 10.11817/j.issn.1672-7347.2022.220245.

DOI:10.11817/j.issn.1672-7347.2022.220245
PMID:36748386
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10930277/
Abstract

The psychological distress of cancer patients seriously affects their therapeutic effects. Effective psychological rehabilitation of cancer patients significantly improves their survival chance and quality of life. Circadian rhythm results from adaptation to the environment during the organism's evolution. When the endogenous clock system is disrupted or the external environment is changed, the body and the environment are out of synchronization, and the circadian rhythm will be disrupted. Circadian rhythm disorder is a common phenomenon in cancer patients, and the changes of circadian rhythm are closely related to their psychological distress. Many studies believe that the circadian rhythm disorder of cancer patients may directly or indirectly affect their psychology through various mechanisms, and targeted intervention by regulating the circadian rhythm of patients may be an essential means to promote the psychological rehabilitation.

摘要

癌症患者的心理困扰严重影响其治疗效果。对癌症患者进行有效的心理康复治疗可显著提高其生存机会和生活质量。昼夜节律是生物在进化过程中适应环境的结果。当内源性时钟系统紊乱或外部环境改变时,机体与环境不同步,昼夜节律就会被打乱。昼夜节律紊乱是癌症患者的常见现象,昼夜节律的变化与他们的心理困扰密切相关。许多研究认为,癌症患者的昼夜节律紊乱可能通过多种机制直接或间接地影响他们的心理,通过调节患者的昼夜节律进行有针对性的干预可能是促进心理康复的重要手段。

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J Pain Symptom Manage. 2022 Feb;63(2):e188-e202. doi: 10.1016/j.jpainsymman.2021.09.010. Epub 2021 Sep 23.
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Prevalence and Determinants of Psychological Distress in Adolescent and Young Adult Patients with Cancer: A Multicenter Survey.青少年和青年癌症患者心理困扰的患病率及影响因素:一项多中心调查
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Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.《全球癌症统计数据 2020:全球 185 个国家和地区 36 种癌症的发病率和死亡率估计》。
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Biological rhythms and chronotherapeutics in depression.抑郁的生物节律与时间治疗学。
Prog Neuropsychopharmacol Biol Psychiatry. 2021 Mar 2;106:110158. doi: 10.1016/j.pnpbp.2020.110158. Epub 2020 Nov 3.
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Melatonin Act as an Antidepressant via Attenuation of Neuroinflammation by Targeting Sirt1/Nrf2/HO-1 Signaling.褪黑素通过靶向Sirt1/Nrf2/HO-1信号通路减轻神经炎症而发挥抗抑郁作用。
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