Satchell P M, Hersch M I
Gordon Craig Laboratory, Department of Surgery, University of Sydney, Australia.
J Neurol Sci. 1988 Nov;87(2-3):289-97. doi: 10.1016/0022-510x(88)90253-5.
Analysis of the discharge characteristics and conduction velocities of single vagal nerve fibres innervating slowly adapting mechanoreceptors in the oesophagus and lungs of acrylamide affected dogs has demonstrated that a group of fibres, the fastest conducting fibres to each organ, fail to conduct. The two failed groups have conduction velocities which are grossly different and yet they have a common receptor type, they have a similar fibre length and they have the same central nervous system destination. Amongst the oesophageal fibres, the failed group with conduction velocities in the upper third of the control range had firing rates which were normally higher than those of the surviving slower conducting fibres (P less than 0.01). The same observation applied to the respiratory fibres (P less than 0.05). It is possible that firing rate is also a factor in predicting the vulnerability of axons in axonopathies.
对丙烯酰胺中毒犬食管和肺中支配慢适应性机械感受器的单根迷走神经纤维的放电特性和传导速度进行分析后发现，一组纤维（即每个器官中传导速度最快的纤维）无法传导。这两组无法传导的纤维传导速度差异极大，但它们具有相同的感受器类型、相似的纤维长度且中枢神经系统靶点相同。在食管纤维中，传导速度处于对照范围上三分之一的失功组的放电频率通常高于存活的传导速度较慢的纤维（P<0.01）。同样的观察结果也适用于呼吸纤维（P<0.05）。放电频率也有可能是预测轴索性神经病中轴突易损性的一个因素。
