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数据资源库——生物系统建模缺失的一环。

Data libraries - the missing element for modeling biological systems.

机构信息

Calico Life Sciences LLC, South San Francisco, CA, USA.

出版信息

FEBS J. 2020 Nov;287(21):4594-4601. doi: 10.1111/febs.15261. Epub 2020 Mar 10.

Abstract

The primary bottleneck in understanding and modeling biological systems is shifting from data collection to data analysis and integration. This process critically depends on data being available in an organized form, so that they can be accessed, understood, and reused by a broad community of scientists. A proven solution for organizing data is literature curation, which extracts, aggregates, and distributes findings from publications. Here, I describe the benefits of extending curation practices to datasets, especially those that are not deposited in centralized databases. I argue that dataset curation (or 'data librarianship' as I suggest we call it) will overcome many barriers in data visibility and reusability and make a unique contribution to integration and modeling.

摘要

理解和建模生物系统的主要瓶颈正从数据收集转移到数据分析和整合。这一过程严重依赖于数据以有组织的形式提供,以便广大科学家能够访问、理解和重复使用这些数据。组织数据的一种经过验证的解决方案是文献整理,它从出版物中提取、汇总和分发研究结果。在这里,我描述了将策展实践扩展到数据集的好处,特别是那些没有存储在集中式数据库中的数据集。我认为,数据集策展(或者我建议我们称之为“数据图书馆学”)将克服数据可见性和可重用性方面的许多障碍,并为整合和建模做出独特的贡献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abc/7687078/aba23d774f31/FEBS-287-4594-g001.jpg

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