Worldwide laser institute, Dallas, TX, USA.
Department of Dermatology, Bangalore Medical College and Research Institute, Bangalore, India.
J Cosmet Dermatol. 2020 Jun;19(6):1278-1283. doi: 10.1111/jocd.13340. Epub 2020 Feb 26.
Acne vulgaris is a chronic disfiguring inflammatory disease of adolescents and adults affecting up to 90% of the population around the world. The sequence of etiopathogenesis in acne is not completely understood but involves abnormalities in sebum production, follicular plugging, proliferation of propionibacterium acnes, and chronic inflammation.
This review aims to summarize the features of the topical selective RAR agonists in treating acne vulgaris with a special emphasis on the 4th generation topical retinoid trifarotene.
Studies were identified by searching electronic databases (MEDLINE and PubMed) till August 2019 and reference lists of respective articles. Only articles published in English language were included.
Topical retinoids have been first line of treatment for more than 30 years now in treating mild to moderate acne vulgaris. Third generation retinoids like adapalene and tazarotene are selective RAR and γ agonists, having an additional anti-inflammatory action along with their comedolytic effects and work well in combinations with topical antibiotics, due to the stability of chemical composition.
Trifarotene is a new 4th generation retinoid with selective action on RAR-γ receptor alone, which is specific for skin, and it is safe for long-term maintenance therapy with good efficacy and tolerability.
寻常痤疮是一种影响全球多达 90%人群的青少年和成年人慢性毁容性炎症性疾病。痤疮的发病机制尚不完全清楚，但涉及皮脂产生、毛囊堵塞、痤疮丙酸杆菌增殖和慢性炎症的异常。
本综述旨在总结局部选择性 RAR 激动剂治疗寻常痤疮的特点，特别强调第四代局部维 A 酸三呋替恩。
通过搜索电子数据库（MEDLINE 和 PubMed）至 2019 年 8 月，并查阅各自文章的参考文献列表，确定研究。仅纳入以英文发表的文章。
局部维 A 酸类药物作为治疗轻度至中度寻常痤疮的一线药物已有 30 多年的历史。第三代维 A 酸如阿达帕林和他扎罗汀是选择性 RAR 和 γ 激动剂，除了具有溶粉刺作用外，还具有抗炎作用，并且由于其化学组成的稳定性，与局部抗生素联合使用效果良好。
三呋替恩是一种新型第四代维 A 酸，仅对 RAR-γ 受体具有选择性，对皮肤具有特异性，具有良好的疗效和耐受性，可安全用于长期维持治疗。
