Windsor Clinical Research Inc, Ontario, Canada.
Department of Medicine, University of Western Ontario, Windsor Campus, Canada.
J Cutan Med Surg. 2023 Jul-Aug;27(4):368-374. doi: 10.1177/12034754231163542. Epub 2023 Mar 16.
Topical retinoids have an essential role in treatment of acne. Trifarotene, a topical retinoid selective for retinoic acid receptor (RAR) γ, is the most recent retinoid approved for treatment of acne. RAR-γ is the most common isoform of RARs in skin, and the strong selectivity of trifarotene for RAR-γ translates to efficacy in low concentration. Trifarotene, like other topical retinoids, acts by increasing keratinocyte differentiation and decreasing proliferation, which reduces hyperkeratinization. Retinoids have also been shown to inhibit inflammatory pathways via effects on leukocyte migration, toll-like receptors, and Activator Protein (AP)-1. Large-scale randomized, controlled clinical trials have demonstrated trifarotene to be safe, well tolerated, and efficacious in reducing both comedones and papules/pustules of acne. However, unlike all other retinoids, trifarotene is the first topical retinoid with rigorous clinical data on safety and efficacy in truncal acne. Data supporting use of trifarotene to manage acne are reviewed in this publication.
局部维 A 酸在痤疮治疗中具有重要作用。曲法罗汀是一种局部维 A 酸，对维 A 酸受体 (RAR) γ 具有选择性，是最近批准用于治疗痤疮的维 A 酸。RAR-γ 是皮肤中 RAR 最常见的亚型，曲法罗汀对 RAR-γ 的高选择性转化为低浓度的疗效。与其他局部维 A 酸一样，曲法罗汀通过增加角质形成细胞分化和减少增殖来发挥作用，从而减少过度角化。维 A 酸还通过影响白细胞迁移、Toll 样受体和激活蛋白 (AP)-1 来抑制炎症途径。大规模随机对照临床试验表明，曲法罗汀安全、耐受良好，能有效减少粉刺和丘疹/脓疱型痤疮。然而，与所有其他维 A 酸不同的是，曲法罗汀是第一个在躯干痤疮的安全性和疗效方面具有严格临床数据的局部维 A 酸。本文综述了支持使用曲法罗汀治疗痤疮的相关数据。
