Ingham H R, Hood F J, Bradnum P, Tharagonnet D, Selkon J B
Br J Oral Surg. 1977 Mar;14(3):264-9. doi: 10.1016/0007-117x(77)90035-x.
The efficacy of metronidazole in the treatment of acute dental infections was investigated and compared with parenteral penicillin in a controlled trial. All 37 patients in the trial responded satisfactorily and metronidazole appeared to be as effective as parenteral penicillin. A further 24 patients treated with metronidazole also responded satisfactorily. Bacteriological studies of pus obtained from 25 patients revealed the presence of many species of obligate anaerobes. Since metronidazole is only active against obligate anaerobic bacteria it is concluded that these organisms are the important pathogens in acute dental infections.
在一项对照试验中，研究了甲硝唑治疗急性牙齿感染的疗效，并与注射用青霉素进行了比较。试验中的37名患者均反应良好，甲硝唑似乎与注射用青霉素一样有效。另外24名接受甲硝唑治疗的患者反应也令人满意。对从25名患者身上获取的脓液进行的细菌学研究显示存在多种专性厌氧菌。由于甲硝唑仅对专性厌氧菌有活性，因此得出结论，这些微生物是急性牙齿感染中的重要病原体。
