破伤风的治疗：一项比较普鲁卡因青霉素和甲硝唑疗效的开放性研究。
Treatment of tetanus: an open study to compare the efficacy of procaine penicillin and metronidazole.
作者信息
Ahmadsyah I, Salim A
出版信息
Br Med J (Clin Res Ed). 1985 Sep 7;291(6496):648-50. doi: 10.1136/bmj.291.6496.648.
Abstract
A prospective, open, non-randomised clinical trial was carried out to compare the efficacy of procaine penicillin with metronidazole in the treatment of moderate tetanus among 173 patients. Patients in the metronidazole group had a significantly lower mortality rate, a shorter stay in hospital, and an improved response to treatment. These results establish the value of antimicrobial treatment in the management of tetanus and show that metronidazole is more efficacious than penicillin in this respect.
摘要
开展了一项前瞻性、开放性、非随机临床试验，以比较普鲁卡因青霉素与甲硝唑治疗173例中度破伤风患者的疗效。甲硝唑组患者的死亡率显著较低，住院时间较短，治疗反应有所改善。这些结果确立了抗菌治疗在破伤风管理中的价值，并表明在这方面甲硝唑比青霉素更有效。
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