Department of Natural Products Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
J Nat Prod. 2020 Apr 24;83(4):1229-1237. doi: 10.1021/acs.jnatprod.9b01269. Epub 2020 Feb 26.
Thirty-two diterpenoids were obtained from the root bark of , and, among them, five compounds (pinmassins A-E) were identified as undescribed analogues. Spectroscopic methods, X-ray single-crystal diffraction analysis, and ECD calculations were applied to establish the structure of the new isolates. Pinmassin D () and abieta-8,11,13,15-tetraen-18-oic acid () showed moderate phosphodiesterase type 4D (PDE4D) inhibitory effects with IC values of 2.8 ± 0.18 and 3.3 ± 0.50 μM, respectively, and their binding modes were investigated by a molecular docking study.
从根皮中分离得到 32 个二萜类化合物，其中 5 个化合物（pinmassins A-E）被鉴定为未见报道的类似物。采用光谱方法、X 射线单晶衍射分析和 ECD 计算确定了新分离物的结构。Pinmassin D () 和 abieta-8,11,13,15-tetraen-18-oic acid () 对磷酸二酯酶 4D（PDE4D）表现出中等抑制作用，IC 值分别为 2.8 ± 0.18 和 3.3 ± 0.50 μM，通过分子对接研究探讨了它们的结合模式。
