Département des Sciences Fondamentales, Chaire de Recherche sur les Agents Anticancéreux d'Origine Naturelle, Université du Québec à Chicoutimi, Québec G7H 2B1, Canada.
Molecules. 2012 Aug 13;17(8):9716-27. doi: 10.3390/molecules17089716.
Three new diterpenoids, namely 7α-hydroxyabieta-8,11,13,15-tetraen-18-oic acid, 7β,15,18-trihydroxyabieta-8,11,13-triene, 13,15-dihydroxypodocarpa-8,11,13-triene, and 12 other known compounds were isolated from buds of Pinus banksiana Lamb. All these compounds, except for 7-oxodehydroabietinol, were isolated for the first time from this plant. Their structures were elucidated by detailed spectroscopic studies and comparison with published data. All isolated compounds were tested for cytotoxic and antibacterial activities. Overall, two compounds, 7-oxodehydroabietinol and 18-nor-4,15-dihydroxyabieta-8,11,13-trien-7-one, showed moderate cytotoxicity against a human lung carcinoma cell line.
从银杉的芽中分离得到了 3 种新的二萜类化合物，分别为 7α-羟基枞-8,11,13,15-四烯-18-酸、7β,15,18-三羟基枞-8,11,13-三烯、13,15-二羟基罗汉松-8,11,13-三烯，以及其他 12 种已知化合物。除了 7-氧代去氢枞醇外，所有这些化合物均为首次从该植物中分离得到。通过详细的光谱研究和与已发表数据的比较，确定了它们的结构。对所有分离得到的化合物进行了细胞毒性和抗菌活性测试。总的来说，有两种化合物，即 7-氧代去氢枞醇和 18-降-4,15-二羟基枞-8,11,13-三烯-7-酮，对人肺癌细胞系表现出中等的细胞毒性。
