Service de médecine nucléaire, Université de Lille, Lille, France.
Service des Maladies du Sang, Université de Lille, Lille, France.
Leuk Lymphoma. 2020 Jul;61(7):1584-1591. doi: 10.1080/10428194.2020.1728750. Epub 2020 Feb 26.
We retrospectively investigated the prognostic value of the metabolic bulk volume (MBV), defined as the metabolic volume of the largest lesion, in 106 patients with diffuse large B-cell lymphoma who underwent baseline FDG PET-CT. Semi-automatically segmented (41% SUV) total metabolic tumor volume (TMTV) and MBV underwent receiver operating characteristic analysis, identifying optimal thresholds of 147 cm for the TMTV and 41.5 cm for the MBV. A low TMTV and a low MBV were significantly associated with longer progression-free survival (PFS) and overall survival (OS). According to Cox multivariate analysis, the TMTV and MBV were independent predictors, respectively, for PFS (HR = 3.501), and OS (HR = 7.242). The TMTV and MBV classification were discordant in 18.9% of patients with a 5-year PFS rate of 100% for patients with low MBV/high TMTV and 74% for high MBV/low TMTV. The baseline MBV can be an efficient tool for the risk stratification of aggressive lymphoma.
我们回顾性研究了代谢体体积（MBV）在 106 例接受基线 FDG PET-CT 的弥漫性大 B 细胞淋巴瘤患者中的预后价值，MBV 定义为最大病变的代谢体积。对半自动分割的（41% SUV）总代谢肿瘤体积（TMTV）和 MBV 进行了接收者操作特征分析，确定 TMTV 的最佳阈值为 147cm，MBV 的最佳阈值为 41.5cm。低 TMTV 和低 MBV 与更长的无进展生存期（PFS）和总生存期（OS）显著相关。根据 Cox 多变量分析，TMTV 和 MBV 分别是 PFS（HR = 3.501）和 OS（HR = 7.242）的独立预测因素。在 18.9%的患者中，TMTV 和 MBV 分类不一致，低 MBV/高 TMTV 患者的 5 年 PFS 率为 100%，而高 MBV/低 TMTV 患者的 5 年 PFS 率为 74%。基线 MBV 可作为侵袭性淋巴瘤风险分层的有效工具。
