School of Community & Environmental Health, College of Health Sciences, Old Dominion University, Norfolk, VA23508, USA.
Department of Food Science and Nutrition, College of Life Sciences, Kuwait University, Kuwait.
Br J Nutr. 2020 Jun 14;123(11):1302-1311. doi: 10.1017/S0007114520000720. Epub 2020 Feb 26.
This study aimed to investigate the association between 25-hydroxyvitamin D (25(OH)D) level and low back pain (LBP) among adolescents while adjusting for potential confounders pertinent to this age group including the weight of school bags, BMI and physical activity. A cross-sectional study was conducted on 760 randomly selected adolescents in middle schools. Data on LBP and the risk factors for LBP were collected from parents by a self-administered questionnaire and from adolescents by face-to-face interview. Blood samples were tested in an accredited laboratory; and 25(OH)D was measured using liquid chromatography-tandem MS. The lifetime prevalence and the 6-month prevalence of LBP were 32·28 (95 % CI 28·97, 35·73) % and 21·26 (95 % CI 18·40, 24·33) %, respectively. There was no difference in the geometric mean of 25(OH)D between those with and without LBP in the past 6 months (28·50 nmol/l and 30·82 nmol/l, respectively; P = 0·122). There was no association between 25(OH)D and LBP in the univariable or multivariable analysis whether 25(OH)D fitted as a continuous or as a categorical variable. We found no association between vitamin D level and LBP in adolescents in an area with high prevalence of vitamin D deficiency. Although it is important to have sufficient vitamin D levels during adolescence for several other health benefits, we concluded that vitamin D is not a major determinant for LBP among adolescents in our setting.
本研究旨在探讨血清 25-羟维生素 D [25(OH)D]水平与青少年腰痛（LBP）之间的关联，同时调整了与该年龄段相关的潜在混杂因素，包括书包重量、BMI 和体力活动。对随机抽取的 760 名中学生进行了横断面研究。采用自填式问卷收集家长的腰痛和腰痛相关危险因素数据，面对面访谈收集青少年的数据。在认可的实验室检测血样；采用液相色谱-串联质谱法检测 25(OH)D。LBP 的终身患病率和 6 个月患病率分别为 32.28%（95%CI：28.97，35.73）和 21.26%（95%CI：18.40，24.33）。在过去 6 个月内有和无 LBP 的人群，25(OH)D 的几何均数无差异（分别为 28.50 nmol/L 和 30.82 nmol/L，P=0.122）。在单变量或多变量分析中，无论 25(OH)D 作为连续变量还是分类变量拟合，25(OH)D 与 LBP 之间均无关联。在维生素 D 缺乏症高发地区的青少年中，维生素 D 水平与 LBP 之间无关联。尽管青少年有足够的维生素 D 水平对其他健康有益，但我们的结论是，在我们的环境中，维生素 D 不是青少年 LBP 的主要决定因素。
