Al-Sabah Reem, Al-Taiar Abdullah, Shaban Lemia, Albatineh Ahmed N, Sharaf Alddin Reem, Durgampudi Praveen K
Department of Community Medicine and Behavioral Sciences, Faculty of Medicine, Kuwait University, Kuwait, Kuwait.
School of Community & Environmental Health, College of Health Sciences, Old Dominion University, 4608 Hampton Blvd, 3136 Health Sciences Building, Norfolk, VA, 23508, USA.
Child Adolesc Psychiatry Ment Health. 2022 Jun 27;16(1):53. doi: 10.1186/s13034-022-00489-4.
This study aimed to investigate the association between 25-hydroxyvitamin D (25(OH)D) and depression symptoms among adolescents in Kuwait, a country with a high prevalence of vitamin D deficiency.
A school based cross-sectional study was conducted on randomly selected 704 adolescents in middle schools. Data on depression symptoms were collected using the Children's Depression Inventory (CDI). Data on covariates were collected from the parents by self-administered questionnaire and from adolescents by face-to-face interview. Blood samples were analyzed in an accredited laboratory; and 25(OH)D was measured using liquid chromatography-tandem mass spectrometry.
Of 704 adolescents, 94 (13.35%; 95%CI:10.35-17.06%) had depression symptom (a score of 19 or more on the CDI). There was no significant difference in the median CDI score between different vitamin D status (p = 0.366). There was also no significant correlation between serum 25(OH)D concentration and CDI score (Spearman's rank correlation = 0.01; p = 0.825).There was no significant association between 25(OH)D and depression symptoms whether 25(OH)D was fitted as a continuous variable (crude odds ratio (OR) 0 .99 [95%CI: 0.98, 1.01], p = 0.458 and adjusted OR 1.01 [95%CI: 0.99, 1.02], p = 0.233), categorical variable as per acceptable cut-of points (crude analysis p = 0.376 and adjusted analysis p = 0.736), or categorical variable as quartiles (crude analysis p = 0.760 and adjusted analysis p = 0.549).
Vitamin D status does not seem to be associated with depression symptoms among adolescents in our setting. Nevertheless, it is important to have sufficient vitamin D levels during adolescence for several other health benefits.
科威特是维生素D缺乏症高发国家，本研究旨在调查该国青少年中25-羟基维生素D（25(OH)D）与抑郁症状之间的关联。
对随机抽取的704名中学青少年进行了一项基于学校的横断面研究。使用儿童抑郁量表（CDI）收集抑郁症状数据。协变量数据通过家长自行填写问卷和与青少年面对面访谈收集。血液样本在一家经认可的实验室进行分析；使用液相色谱-串联质谱法测量25(OH)D。
704名青少年中，94名（13.35%；95%CI：10.35-17.06%）有抑郁症状（CDI得分19分及以上）。不同维生素D状态之间的CDI中位数得分无显著差异（p = 0.366）。血清25(OH)D浓度与CDI得分之间也无显著相关性（斯皮尔曼等级相关性 = 0.01；p = 0.825）。无论将25(OH)D作为连续变量（粗优势比（OR）0.99 [95%CI：0.98, 1.01]，p = 0.458；调整后OR 1.01 [95%CI：0.99, 1.02]，p = 0.233）、根据可接受切点作为分类变量（粗分析p = 0.376；调整分析p = 0.736）还是作为四分位数的分类变量（粗分析p = 0.760；调整分析p = 0.549），25(OH)D与抑郁症状之间均无显著关联。
在我们的研究环境中，维生素D状态似乎与青少年的抑郁症状无关。然而，青春期保持充足的维生素D水平对其他多种健康益处很重要。
