Palabıyık Mehmet Taner, Akalın Yavuz, Yalçın Ömer, Şahin İsmail Gökhan, Çevik Nazan, Öztürk Alpaslan
University of Health Sciences, Health Application and Research Center,Yüksek İhtisas Training and Research Hospital, Department of Orthopedics and Traumatology, Bursa, Turkey.
University of Health Sciences, Health Application and Research Center,Yüksek İhtisas Training and Research Hospital, Department of Pathology, Bursa, Turkey.
Ortop Traumatol Rehabil. 2019 Dec 31;21(6):437-446. doi: 10.5604/01.3001.0013.7401.
To investigate the effects of hyperbaric oxygen (HBO) and pentoxifylline (PTX) treatment on osteotendinous junction healing of Achilles tendon in an animal model.
Thirty-six adult female Wistar-albino rats were randomly divided into three groups as control, PTX and HBO groups with a total of 12 rats per group. Under general anesthesia, the Achilles tendons were cut at the level of the osteotendinous junction and repaired. After the surgery, no treatment was given to the control group. Fifty mg/kg intraperitoneal PTX was administered to the PTX group daily for 1 week. The HBO group was exposed to 2,5 atmospheric pressure, 100% oxygen for 2 hours daily for 1 week. All animals were sacrificed at the end of sixth week. Biomechanical tests and histological examinations were performed.
Energy absorption was significantly higher in the PTX group than that in the control group after biomechanical tests (p=0.010). Histopathological evaluation results revealed no difference between the groups: however, hyalinization level was relatively better in the HBO group than that in the control group (p=0.026).
在动物模型中研究高压氧（HBO）和己酮可可碱（PTX）治疗对跟腱骨腱结合部愈合的影响。
将36只成年雌性Wistar白化大鼠随机分为对照组、PTX组和HBO组，每组12只。在全身麻醉下，于骨腱结合部水平切断跟腱并进行修复。术后，对照组不给予任何治疗。PTX组每天腹腔注射50mg/kg PTX，持续1周。HBO组每天暴露于2.5个大气压、100%氧气环境中2小时，持续1周。所有动物在第六周结束时处死。进行生物力学测试和组织学检查。
生物力学测试后，PTX组的能量吸收显著高于对照组（p = 0.010）。组织病理学评估结果显示各组之间无差异；然而，HBO组的透明变性水平相对优于对照组（p = 0.026）。
