School of Pharmacy, Jiangsu University, 212013, China.
Department of Preventive Medicine and Public Health Laboratory Science, School of Medicine, Jiangsu University, 212013, China.
J Mater Chem B. 2020 Mar 18;8(11):2331-2342. doi: 10.1039/c9tb01604j.
Multi-component combination therapy of cancer is currently a hot spot in the field of cancer treatment research. In this study, a WS2 nanosheet was selected as the substrate material and modified with a cell-like membrane biomimetic liposome (WS2-lipid). The lipid-modified WS2 nanomaterials were successfully prepared with good stability and biocompatibility. Its good photothermal characteristics and high drug loading amount were utilized to achieve a comprehensive chemo and photothermal therapeutic effect. The results showed that the lipid coating strongly enhanced the stability of the WS2 nanosheets before and after DOX loading and the WS2-lipid had a good photothermal performance and drug loading amount. According to the cellular results, WS2-lipid was able to be taken up by MCF-7 cells. Both photothermo-therapy and chemotherapy had a concentration dependent cytotoxicity on MCF-7 cells, and the combined application of both methods had an improved cytotoxicity. In addition, in vivo photothermal experiments indicated that lipid modification could promote intratumoral accumulation of the material. Thus, WS2-lipid can be used as a good nano-platform for phototherapy and chemotherapy combination therapy and has good application prospects in cancer therapy.
癌症的多组分联合治疗目前是癌症治疗研究领域的一个热点。本研究选择 WS2 纳米片作为基底材料，并对其进行细胞膜仿生脂质体（WS2-脂质体）的修饰。成功制备了具有良好稳定性和生物相容性的脂质修饰 WS2 纳米材料，其具有良好的光热特性和高载药量，实现了全面的化学和光热治疗效果。结果表明，脂质涂层强烈增强了 DOX 负载前后 WS2 纳米片的稳定性，WS2-脂质体具有良好的光热性能和载药量。根据细胞结果，WS2-脂质体能够被 MCF-7 细胞摄取。光热疗法和化学疗法对 MCF-7 细胞均具有浓度依赖性细胞毒性，两种方法联合应用具有改善的细胞毒性。此外，体内光热实验表明，脂质修饰可以促进材料在肿瘤内的积累。因此，WS2-脂质体可用作光疗和化疗联合治疗的良好纳米平台，在癌症治疗中具有良好的应用前景。
